Next-generation cancer treatment: exploring the tumor microenvironment and CAR-T cell therapy potential

被引：0

作者：

Muhammadul-Awwal Irodatullah Bisola ^{[1
]}

Ikponmwosa Jude Ogieuhi ^{[2
]}

Victor Oluwatomiwa Ajekiigbe ^{[3
]}

Michael Olufemi Adegbola ^{[4
]}

Chidinma Ifunanyachukwu Udojike ^{[1
]}

Ganiyat Adekemi Adeshina ^{[1
]}

Afeez Oladipupo Ogidan ^{[5
]}

Reem Gamaleldin Hassan Mohamed ^{[6
]}

Nathnael Abera Woldehana ^{[7
]}

Adewunmi Akingbola ^{[8
]}

Olanrewaju Adeniran ^{[9
]}

机构：

[1] University of Lagos,Department of Surgery

[2] Siberian State Medical University,Department of Public Health

[3] Ladoke Akintola University of Technology,undefined

[4] Olabisi Onabanjo University Teaching Hospital,undefined

[5] Alimosho general hospital,undefined

[6] Lagos state Health service commission,undefined

[7] Badr General Hospital,undefined

[8] Johns Hopkins University,undefined

[9] University of Cambridge Cambridgeshire Old Trinity Schools,undefined

[10] West Virginia University,undefined

来源：

Discover Medicine | / 2卷 / 1期

关键词：

CAR-T; Tumor; Microenvironment; Oncology; Immunology;

D O I：

10.1007/s44337-025-00253-5

中图分类号：

学科分类号：

摘要：

Cancer is still one of the most common causes of death worldwide; the tumor microenvironment plays a key role in cancer development and treatment resistance. It has been reported that CAR-T cell immunotherapy is one of the most promising approaches. However, when considering solid tumors, difficulties are posed by TME complexity and its immunosuppressive nature.

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