Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification

被引：0
|
作者：
Yi Li Xu [1 ,2 ]
Mei Huang [1 ]
Yang Zhang [3 ]
Xin Ying Su [2 ]
Min Huang [1 ]
Nan Yu Zou [1 ]
Yu Rui Jiao [1 ]
Yu Chen Sun [1 ]
Ling Liu [1 ]
Yong Hua Lei [2 ]
Chang Jun Li [1 ,4 ,5 ,6 ]
机构：
[1] Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University
[2] Department of Orthodontics,Xiangya Hospital, Central South University
[3] Xiangya School of Medicine, Central South University
[4] Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University
[5] National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
[6] Laboratory Animal Center, Xiangya Hospital, Central South
来源：
Bone Research | 2025年 / 13卷 / 01期
关键词：
D O I：
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中图分类号：
R329.2 [人体细胞学];
学科分类号：
摘要：
<正>Mechanical stress modulates bone formation and organization of the extracellular matrix(ECM), the interaction of which affects heterotopic ossification(HO). However, the mechanically sensitive cell populations in HO and the underlying mechanism remain elusive. Here, we show that the mechanical protein Polysyctin-1(PC1, Pkd1) regulates CTSK lineage tendon-derived mesenchymal stem cell(TDMSC) fate and ECM organization, thus affecting HO progression.
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页码：183 / 196
页数：14
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