Novel Pro-myogenic Factor Neoruscogenin Induces Muscle Fiber Hypertrophy by Inhibiting MSTN Maturation and Activating the Akt/mTOR Pathway

被引：0

作者：

Zhang, Dingding ^{[1
]}

Tao, Jingli ^{[1
]}

Zhang, Xuan ^{[1
]}

Ma, Xiangfei ^{[1
]}

Li, Chengyu ^{[1
]}

Li, Hongmin ^{[1
]}

Li, Weijian ^{[1
]}

Chen, Jie ^{[1
]}

Liu, Honglin ^{[1
]}

机构：

[1] Nanjing Agr Univ, Dept Anim Genet Breeding & Reprod, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2022年 / 71卷 / 01期

基金：

中国国家自然科学基金;

关键词：

neoruscogenin; MSTN; muscle fiber hypertrophy; myoblast differentiation; muscle injury repair; MYOFIBRILLAR PROTEIN-SYNTHESIS; MYOSTATIN GENE MSTN; SKELETAL-MUSCLE; NEGATIVE REGULATOR; RUSCUS EXTRACT; DIFFERENTIATION; EXPRESSION; ATROPHY; KINASE; GROWTH;

D O I：

暂无

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Neoruscogenin is a plant-origin sapogenin that has the potential to modulate muscle growth among the small-molecule compounds that we previously predicted by artificial intelligence to target myostatin (MSTN). This study aimed to elucidate the biological role of neoruscogenin on muscle growth and its relationship with MSTN. Using molecular biological techniques, we found that neoruscogenin inhibited MSTN maturation, thereby repressing its signal transduction; further facilitated protein synthesis metabolism and reduced protein degradation metabolism, ultimately promoting the differentiation of myoblasts and hypertrophy of muscle fibers; and had the effect of repairing muscle injury. This study enriched the biological functions of neoruscogenin and provided a theoretical basis for the treatment of human myopathy and its application in the livestock industry.

引用

页码：499 / 511

页数：13