Protective effect of Dendrobium officinale extract on aspirin-induced gastric lesions in rats

被引：0

作者：

Wang, Xinran ^{[1
]}

Xiong, Huazhong ^{[2
]}

Qiao, Juhui ^{[1
]}

Zhang, Wanying ^{[1
]}

Wang, Siming ^{[1
]}

Liu, Meichen ^{[1
]}

Liu, Shichao ^{[3
]}

机构：

[1] Changchun Univ Chinese Med, Northeast Asian Inst Tradit Chinese Med, 1035 Boshuo Rd, Changchun 130117, Jilin, Peoples R China

[2] Changchun Univ, Prevent & Treatment Ctr, Chinese Med Affiliated Hosp, l30000, Changchun, Peoples R China

[3] Changchun Univ Chinese Med, Sch Pharm, Changchun 130117, Peoples R China

来源：

MOLECULAR IMMUNOLOGY | 2025年 / 179卷

关键词：

Dendrobium officinale; Gastric mucosa; Aspirin; Antioxidant; Inflammatory mediators; INFLAMMATION; ULCER;

D O I：

10.1016/j.molimm.2025.01.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To examine the protective effect and mechanism of the original extract of Dendrobium officinale (DE) on gastric lesions caused by aspirin (ASA) facilitate the development of traditional Chinese medicine products. In this study, a gastric lesions rat model was established, and then the rats were treated with DE for 5 days. We found that ASAinduced gastric mucosal detachment and hemorrhagic lesions in rats improved after DE supplementation. Meanwhile, effectively inhibits the secretion of inflammatory mediators (IL-6, IL-1 beta, TNF-alpha, MPO, COX-2) and upregulates the activity of antioxidant core components (T-SOD, GSH-Px) and defense factors (TFFs, EGF, EGFR) in gastric tissues. It was further found that DE exerted a defensive effect on the gastric mucosa in association with NF-kappa B/Nrf-2/HO-1 signaling. In conclusion, DE protects the gastric mucosa from oxidative stress, improves its defenses, as well as being a potential gastric mucosal nutrient in the future, preventing ASA-induced gastric lesions.

引用

页码：42 / 51

页数：10

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