Enhancing CAR-T Therapy in CLL By Modulating the Immunosuppressive Tumor Microenvironment: A Novel Approach with Significant Therapeutic Potential

被引：0
|
作者：
Palma, Angimar Uriepero [1 ]
Uarela, Melanie Mediavilla [2 ]
Marquez, Maria Elena [3 ]
Gamal, Wael [2 ]
Ammad-ud-din, Mohammad [4 ]
Oppezzo, Pablo [5 ]
Sahakian, Eva [6 ]
Pinilla-Ibarz, Javier [7 ]
机构：
[1] Jefferson Einstein Hosp, Dept Internal Med, Philadelphia, PA USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Immunol Immune Oncol, Tampa, FL USA
[3] Inst Pasteur Montevi, Res Lab Chron Lymphocyt Leukemia, Montevideo, Uruguay
[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Hematol Oncol, Tampa, FL USA
[5] Inst Pasteur Montevideo, Montevideo, Uruguay
[6] H Lee Moffitt Canc Ctr & Res Inst, Dept Immunol, Tampa, FL USA
[7] H Lee Moffitt Canc Ctr & Res Inst, Malignant Hematol, Tampa, FL USA
来源：
BLOOD | 2024年 / 144卷
关键词：
D O I：
10.1182/blood-2024-204892
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：4607 / 4608
页数：2
相关论文
共 50 条
  • [21] 3D IN VITRO TUMOR MICROENVIRONMENT MODELS FOR SCREENING CAR-T CELL THERAPY EFFICACY
    Xue, Bin
    Vermond, Sophie
    Herbrand, Ulrike
    Harris, David
    Moiset, Gemma
    Hribar, Kolin
    Schuler, Julia
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A314 - A314
  • [22] Nattokinase-Mediated Regulation of Tumor Physical Microenvironment to Enhance Chemotherapy, Radiotherapy, and CAR-T Therapy of Solid Tumor
    Zhang, Yanxiang
    Pei, Pei
    Zhou, Hailin
    Xie, Yuyuan
    Yang, Sai
    Shen, Wenhao
    Hu, Lin
    Zhang, Yujuan
    Liu, Teng
    Yang, Kai
    ACS NANO, 2023, 17 (08) : 7475 - 7486
  • [23] Unleashing the Therapeutic Potential of CAR-T Cell Therapy Using Gene-Editing Technologies
    Jung, In-Young
    Lee, Jungmin
    MOLECULES AND CELLS, 2018, 41 (08) : 717 - 723
  • [24] Enhancing CAR-T cell therapy against solid tumor by drug-free triboelectric immunotherapy
    Li, Haimei
    Wang, Zichen
    Hu, Yulin
    He, Guangqin
    Huang, Liang
    Liu, Yi
    Wang, Zhong Lin
    Jiang, Peng
    BIOMATERIALS, 2025, 314
  • [25] An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment
    Wang, Yi
    Jiang, Hua
    Luo, Hong
    Sun, Yansha
    Shi, Bizhi
    Sun, Ruixin
    Li, Zonghai
    FRONTIERS IN IMMUNOLOGY, 2019, 10 : 1691
  • [26] Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy
    Li, Weizhen
    Zhou, Yang
    Wu, Zhongen
    Shi, Yaoping
    Tian, Enming
    Zhu, Yingqi
    Wang, Tao
    Dou, Wei
    Meng, Xiangjing
    Chen, Ming
    Zhai, Bo
    Zhu, Di
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [27] A Novel CAR-T Cell Therapy Strategy to Inhibit Hepatocyte Growth Factor in Solid Tumor
    Jeon, Yeongha
    Ju, Anna
    Lee, Narim
    Kim, Min-Gu
    Kim, Minjoo
    Lee, Sangeun
    Lee, Song-Jae
    Song, Seong-Won
    MOLECULAR THERAPY, 2022, 30 (04) : 317 - 318
  • [28] CXCL11-armed oncolytic adenoviruses enhance CAR-T cell therapeutic efficacy and reprogram tumor microenvironment in glioblastoma
    Wang, Guoqing
    Zhang, Zongliang
    Zhong, Kunhong
    Wang, Zeng
    Yang, Nian
    Tang, Xin
    Li, Hexian
    Lu, Qizhong
    Wu, Zhiguo
    Yuan, Boyang
    Zheng, Meijun
    Cheng, Ping
    Tong, Aiping
    Zhou, Liangxue
    MOLECULAR THERAPY, 2023, 31 (01) : 134 - 153
  • [29] Comparative evaluation of CAR-NK and CAR-T cell therapy for HNSCC: a novel approach with enhanced accessibility and safety
    Hernandez-Gamarra, M.
    Dominguez, E.
    Veiga-Rua, S.
    Salgado-Roo, A.
    Pedrera-Garbayo, L. F.
    Carracedo, A.
    Allegue, C.
    HUMAN GENE THERAPY, 2024, 35 (3-4) : A218 - A218
  • [30] Tumor-tagging by oncolytic viruses: A novel strategy for CAR-T therapy against solid tumors
    Tang, Xin-Ying
    Ding, Yu-Shi
    Zhou, Tao
    Wang, Xu
    Yang, Yong
    CANCER LETTERS, 2021, 503 : 69 - 74
12345