BT8009 monotherapy in enfortumab vedotin (EV)-naive patients (pts) with metastatic urothelial carcinoma (mUC): Updated results of Duravelo-1

被引:1
|
作者
Reig Torras, O. [1 ]
Crouzet, L. [2 ]
Necchi, A. [3 ,4 ]
Baldini, C. [5 ]
Lostes Bardaji, M. J. [6 ,7 ]
Doger de Speville, B. [8 ]
Italiano, A. [9 ,10 ]
Verlingue, L. [11 ]
Boni, V. [12 ]
Carter, L. [13 ,14 ]
Duran, I. [15 ]
Garmezy, B. [16 ]
Galsky, M. D. [17 ]
Falchook, G. S. [18 ]
DeMars, L. [19 ]
Josephs, K. [20 ]
Xu, C. [21 ]
Bader, J. [22 ]
Fontana, E. [23 ]
机构
[1] Hosp Clin Barcelona, Dept Med Oncol, Barcelona, Spain
[2] Ctr Eugene Marquis, UNICANCER, Rennes, France
[3] Univ Vita Salute San Raffaele, Dept Med Oncol, Milan, Italy
[4] IRCCS Osped San Raffaele, Dept Med Oncol, Milan, Italy
[5] Gustave Roussy Canc Campus, Drug Dev Dept DITEP, Villejuif, France
[6] Vall DHebron Univ Hosp, Oncol Dept, Barcelona, Spain
[7] Vall dHebron Inst Oncol, Oncol Dept, Barcelona, Spain
[8] START Madrid FJD Hosp Univ Fdn Jimenez Diaz, Start Madrid Phase Unit 1, Madrid, Spain
[9] Inst Bergonie, Early Phase Trials Unit, Bordeaux, France
[10] Univ Bordeaux, Bordeaux, France
[11] Ctr Leon Berard, Phase Clin Unit 1, Lyon, France
[12] NEXT Madrid, Univers Hosp Quiron Salud Madrid, Madrid, Spain
[13] Univ Manchester, Med Oncol, Manchester, Lancs, England
[14] Christie NHS Fdn Trust, Manchester, Lancs, England
[15] Hosp Univ Marques de Valdecilla IDIVAL, Dept Despacho 271, Santander, Spain
[16] Sarah Cannon Res Inst, Med Oncol, Nashville, TN USA
[17] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY USA
[18] HealthONE, Sarah Cannon Res Inst, Med Oncol, Denver, CO USA
[19] Bicycle Therapeut, Clin Dev, Cambridge, MA USA
[20] Bicycle Therapeut, Clin Sci, Cambridge, MA USA
[21] Bicycle Therapeut, Biostat, Cambridge, MA USA
[22] Bicycle Therapeut, Quantitat Pharmacol, Cambridge, MA USA
[23] Sarah Cannon Res Inst UK, Drug Dev, London, England
关键词
D O I
10.1016/j.annonc.2024.08.718
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
652P
引用
收藏
页码:S515 / S516
页数:2
相关论文
共 50 条
  • [41] Concomitant medications in patients with metastatic urothelial carcinoma receiving enfortumab vedotin: real-world data from the ARON-2EV study
    Fiala, Ondrej
    Buti, Sebastiano
    Fujita, Kazutoshi
    de Liano, Alfonso Gomez
    Fukuokaya, Wataru
    Kimura, Takahiro
    Yanagisawa, Takafumi
    Giannatempo, Patrizia
    Angel, Martin
    Mennitto, Alessia
    Molina-Cerrillo, Javier
    Bourlon, Maria T.
    Soares, Andrey
    Takeshita, Hideki
    Calabro, Fabio
    Ortega, Cinzia
    Kucharz, Jakub
    Milella, Michele
    Seront, Emmanuel
    Park, Se Hoon
    Tural, Deniz
    Benedetti, Giovanni
    Urun, Yuksel
    Battelli, Nicola
    Melichar, Bohuslav
    Poprach, Alexandr
    Buchler, Tomas
    Kopecky, Jindrich
    Conteduca, Vincenza
    Monteiro, Fernando Sabino Marques
    Massari, Francesco
    Gupta, Shilpa
    Santoni, Matteo
    CLINICAL & EXPERIMENTAL METASTASIS, 2025, 42 (02)
  • [42] Enfortumab Vedotin Following Platinum Chemotherapy and Avelumab Maintenance in Patients with Metastatic Urothelial Carcinoma: A Retrospective Data from the ARON-2EV Study
    Fiala, Ondrej
    Massari, Francesco
    Basso, Umberto
    Giannatempo, Patrizia
    Grande, Enrique
    Buti, Sebastiano
    Myint, Zin W.
    De Giorgi, Ugo
    Pichler, Renate
    Grillone, Francesco
    Urun, Yuksel
    Calabro, Fabio
    Bourlon, Maria T.
    Galli, Luca
    Kanesvaran, Ravindran
    Roviello, Giandomenico
    Kucharz, Jakub
    Rizzo, Mimma
    Park, Se Hoon
    Cerbone, Linda
    Seront, Emmanuel
    Messina, Carlo
    Molina-Cerrillo, Javier
    Santini, Daniele
    Yano, Akihiro
    Incorvaia, Lorena
    Catalano, Martina
    Pinto, Alvaro
    Formisano, Luigi
    Soares, Andrey
    Facchini, Gaetano
    Fornarini, Giuseppe
    Poprach, Alexandr
    Rebuzzi, Sara Elena
    Nasso, Cecilia
    Spinelli, Gian Paolo
    Angel, Martin
    Stellato, Marco
    Tural, Deniz
    Aurilio, Gaetano
    Epstein, Ilana
    Carrozza, Francesco
    Monteiro, Fernando Sabino Marques
    Benedetti, Giovanni
    Buchler, Tomas
    Ortega, Cinzia
    Zakopoulou, Roubini
    Battelli, Nicola
    Porta, Camillo
    Bellmunt, Joaquin
    TARGETED ONCOLOGY, 2024, 19 (06) : 905 - 915
  • [43] EV-201: Long-term results of enfortumab vedotin monotherapy for locally advanced or metastatic urothelial cancer previously treated with platinum and PD-1/PD-L1 inhibitors
    O'Donnell, P.
    Galsky, M. D.
    Rosenberg, J. E.
    Petrylak, D. P.
    Balar, A. V.
    McGregor, B. A.
    Heath, E.
    Yu, E. Y.
    Quinn, D. I.
    Hahn, N. M.
    Campbell, M.
    Liang, S-Y.
    Steinberg, J.
    Loriot, Y.
    ANNALS OF ONCOLOGY, 2020, 31 : S579 - S580
  • [44] The double antibody drug conjugate (DAD) phase I trial: Sacituzumab govitecan (SG) plus enfortumab vedotin (EV) as ≥ second-line therapy for metastatic urothelial carcinoma (mUC)
    McGregor, B. A.
    Sonpavde, G. P.
    Kwak, L.
    Gao, X.
    Mantia, C.
    Wei, X. X.
    Berchuck, J. E.
    Ravi, P.
    Michaelson, M. D.
    Choueiri, T. K.
    Bellmunt, J.
    ANNALS OF ONCOLOGY, 2023, 34 : S1199 - S1200
  • [45] Phase Ib trial of erdafitinib (E) combined with enfortumab vedotin (EV) following platinum and PD-1/L1 inhibitors for metastatic urothelial carcinoma (mUC) with FGFR2/3 genetic alterations (GAs).
    Jain, Rohit K.
    Kim, Youngchul
    Rembisz, Jennifer
    Piekarz, Richard
    Synold, Timothy W.
    Zhang, Jingsong
    Sonpavde, Guru P.
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (06)
  • [46] Phase Ib trial of erdafitinib (E) combined with enfortumab vedotin (EV) following platinum and PD-1/L1 inhibitors for metastatic urothelial carcinoma (mUC) with FGFR2/3 genetic alterations (GAs).
    Jain, Rohit K.
    Heiligh, Jazlyn
    Kim, Youngchul
    Piekarz, Richard
    Pelosof, Lorraine Cheryl
    Yang, Yuanquan
    D'souza, Anishka
    Wong, Risa Liang
    Graham, Laura
    Gupta, Sumati
    Park, Anna
    Synold, Timothy W.
    Sonpavde, Guru P.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (4_SUPPL) : 625 - 625
  • [47] Enfortumab vedotin (EV) with pembrolizumab (P) versus chemotherapy (chemo) in previously untreated locally advanced or metastatic urothelial carcinoma (la/mUC): Analysis of cisplatin (cis)-eligible population from EV-302/KEYNOTE-A39
    Bedke, Jens
    Van Der Heijden, Michiel Simon
    Powles, Thomas
    Valderrama, Begona Perez
    Kikuchi, Eiji
    Iyer, Gopa
    Vulsteke, Christof
    Swami, Umang
    Castellano, Daniel
    Sarwar, Naveed
    Drakaki, Alexandra
    Hoffman-Censits, Jean H.
    Arafat, Waddah
    Andabekov, Timur
    Li, Jian-Ri
    Lu, Yi-Tsung
    Yu, Xuesong
    Shetty, Aditya
    Moreno, Blanca Homet
    Gupta, Shilpa
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [48] EV-101: A Phase I Study of Single-Agent Enfortumab Vedotin in Patients With Nectin-4-Positive Solid Tumors, Including Metastatic Urothelial Carcinoma
    Rosenberg, Jonathan
    Sridhar, Srikala S.
    Zhang, Jingsong
    Smith, David
    Ruether, Dean
    Flaig, Thomas W.
    Baranda, Joaquina
    Lang, Joshua
    Plimack, Elizabeth R.
    Sangha, Randeep
    Heath, Elisabeth I.
    Merchan, Jamie
    Quinn, David I.
    Srinivas, Sandy
    Milowsky, Matthew
    Wu, Chunzhang
    Gartner, Elaina M.
    Zuo, Peiying
    Melhem-Bertrandt, Amal
    Petrylak, Daniel P.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (10) : 1041 - +
  • [49] Enfortumab vedotin (EV) with pembrolizumab (P) versus chemotherapy (chemo) in previously untreated locally advanced or metastatic urothelial carcinoma (la/mUC): Analysis of the cisplatin (cis)-ineligible population from EV-302/KEYNOTE-A39
    Van Der Heijden, Michiel Simon
    Gupta, Shilpa
    Bedke, Jens
    Valderrama, Begona Perez
    Kikuchi, Eiji
    Iyer, Gopa
    Loriot, Yohann
    Dawson, Nancy Ann
    Hoffman-Censits, Jean H.
    Mar, Nataliya
    Sridhar, Srikala S.
    Maroto-Rey, Pablo
    Shin, Sang Joon
    Yu, Evan Y.
    Duran, Ignacio
    Birrenkott, Matthew
    Yu, Xuesong
    Shetty, Aditya
    Bavle, Abhishek Amar
    Powles, Thomas
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [50] First-line (1L) enfortumab vedotin plus pembrolizumab demonstrates durable antitumour activity in cisplatin-ineligible patients with locally advanced/metastatic urothelial carcinoma (la/mUC)
    Rosenberg, J. E.
    Flaig, T. W.
    Friedlander, T. W.
    Milowsky, M. I.
    Srinivas, S.
    Petrylak, D. P.
    Merchan, J. R.
    Bilen, M. A.
    Carret, A. -S.
    Yuan, N.
    Sasse, C.
    Hoimes, C. J.
    SWISS MEDICAL WEEKLY, 2020, : 26S - 27S