Research progress of cervicocerebral artery dissection, from mechanism to clinic: A scoping review

Cervicocerebral artery dissection (CAD) commonly occurs in young individuals, and its clinical manifestations lack specificity. It can present as either ischemic or hemorrhagic events. Due to variations in the location, timing of formation, and severity of the lesion in CAD, clinical presentations vary widely, making imaging crucial for accurate diagnosis. Currently, the primary treatment for CAD focuses on anti-thrombotic therapy, and evidence supporting venous thrombolysis is still inconclusive. With advancements in scientific technology, the concepts of the etiology and surgical treatment of CAD continue to evolve over time. As of now, the literature on CAD has experienced an exponential growth in the number of articles. However, there is still a lack of comprehensive discussion on the latest perspectives regarding the pathogenic mechanisms and treatment approaches for CAD. This study combines discussions on the etiology, pathogenesis, clinical characteristics, auxiliary examinations, and treatment of CAD, aiming to provide readers with a comprehensive understanding of CAD. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.