Ion-Pair Extraction with Tetracyanocyclopentadienides: A Method for Estimating Extraction Efficiency

被引：1

作者：

Sakai, Takeo ^{[1
]}

Ota, Masanari ^{[1
]}

Ito, Miho ^{[1
]}

Miura, Riho ^{[1
]}

Fumimoto, Yuto ^{[1
]}

Mori, Yuji ^{[1
]}

机构：

[1] Meijo Univ, Fac Pharm, 150 Yagotoyama Tempaku ku, Nagoya 4688503, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2025年 / 73卷 / 02期

基金：

日本学术振兴会;

关键词：

ion-pair extraction; extraction coefficient; tetrcyanocyclopentadienide; OF-THE-ART; PHYSICOCHEMICAL PARAMETERS; OCTANOL/WATER PARTITION; LOG P; LIPOPHILICITY; COEFFICIENT; PREDICTION; CHEMISTRY; CONSTANTS; CHLORIDE;

D O I：

10.1248/cpb.c24-00630

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ion-pair extraction with tetracyanocyclopentadienides (TCCPs) is an effective method for isolating ammonium cations; however, predicting the extractability of ammonium-TCCP ion pairs is challenging. Herein, the measured extraction coefficients (LogKex) of ammonium-TCCP ion pairs allowed the values of A (an index for anion extractability) for the TCCP anions to be determined (-3.1 to -1.4); these values were higher than and similar to those of perchlorate and picrate anions, respectively. The correlation between LogKex and the sum of the values of A and the calculated Log P of ammonium cations revealed that LogKex can be estimated by the equation LogKex = A + CLOGPNR4 + 1.6, where CLOGPNR4 is the CLOGP value obtained using the "no-plus" ammonium structure. The LogKex value can be used to predict the extractability of quaternary ammonium ions.

引用

页码：121 / 135

页数：15

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