Arechuines A-D, arecoline alkaloids from the peels of Areca catechu L.

被引：0

作者：

Sun, Biao ^{[1
]}

Wu, Yuanning ^{[1
]}

Yang, Jianzhan ^{[2
]}

Zhang, Shiqing ^{[1
]}

Xu, Fangfang ^{[2
]}

Zhang, Xiaoqi ^{[1
]}

机构：

[1] Jinan Univ, Coll Pharm, Guangdong Prov Engn Res Ctr Modernizat TCM, NMPA Key Lab Qual Evaluat TCM, Guangzhou, Peoples R China

[2] Guangzhou Univ Chinese Med, Clin Coll 2, Guangdong Prov Key Lab Res Emergency TCM, Guangzhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2025年

基金：

中国国家自然科学基金;

关键词：

<italic>Areca catechu</italic> L; arecoline alkaloids; structure elucidation; antiepileptic activity; neuroprotective effects; BETEL NUT; GABA;

D O I：

10.1080/14786419.2025.2455460

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four novel arecoline alkaloid atropisomers, arechuines A-D (1 - 4), were obtained from the peels of Areca catechu L. Their structures were elucidated by UV, IR, MS and NMR spectra. The absolute configurations of (+)/(-)-4 were determined by comparing the experimental and calculated ECD spectra. Compounds 1 - 4 were evaluated for their neuroprotective effects in glutamate-induced HT22 cell and 3 revealed potent neuroprotective effects at 10 mu M. These are the first reported arecoline alkaloid atropisomers isolated from A. catechu.

引用

页数：8

共 50 条

[21] Structural Elucidation and Antioxidant Activities of a Neutral Polysaccharide From Arecanut (Areca catechu L.)
Ji, Xiaolong
Guo, Jianhang
Pan, Feibing
Kuang, Fengjun
Chen, Haiming
Guo, Xudan
Liu, Yanqi
FRONTIERS IN NUTRITION, 2022, 9
[22] Advances in chemical constituents of Areca catechu L. and their effects on nervous system
ZHANG Hao
CHEN Xi
ZHANG Danshen
JING Yongshuai
中国药理学与毒理学杂志, 2023, 37 (07) : 501 - 501
[23] Energetics and economics in conventional processing of arecanut (Areca catechu L.) in India
Gunasekar, J. John
Kaleemullah, S.
Doraisamy, P.
Kennedy, Z. John
AMA-AGRICULTURAL MECHANIZATION IN ASIA AFRICA AND LATIN AMERICA, 2007, 38 (04): : 13 - 17
[24] Antioxidant and antimicrobial potential of Areca catechu L. (Arecaceae) inflorescence extracts
Aswany, Thomas
Helen, Pandaravilagam Azariah Mary
Ijinu, Thadiyan Parambil
Sasidharan, Sreejith Pongillyathundiyil
Akhilesh, Valpasseri Purakkat
George, Varughese
Pushpangadan, Palpu
ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL, 2023, 12 (02): : 730 - 744
[25] A phytopharmacological review of the classical Ayurveda drug Puga (Areca catechu L.)
Allam, Ramakrishna
Sahani, Govardhan
Raj, Antony Stephen
Mohammed, Faiz
ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL, 2023, 12 (02): : 180 - 185
[26] Anti-nociceptive effect of total alkaloids isolated from the seeds of Areca catechu L (Arecaceae) in mice
Zhao, Lei
Li, Yu
Yang, Shaohui
Zhang, Pei
Wang, Jing
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2017, 16 (02) : 363 - 369
[27] PRODUCTION AND PARTIAL PURIFICATION OF FUNGAL PECTINASES FROM ARECA NUT (ARECA CATECHU L.) HUSK WASTE UNDER SUBMERGED FERMENTATION
Naveenkumar, Kudureru Jayanna
Thippeswamy, Basaiah
Krishnappa, Madappa
INTERNATIONAL JOURNAL OF ADVANCED BIOTECHNOLOGY AND RESEARCH, 2014, 5 (02): : 188 - 201
[28] Improved Viability of Areca (Areca catechu L.) Seedlings under Drought Stress Using a Superabsorbent Polymer
Li, Jia
Liu, Liyun
Zhou, Huanqi
Li, Meng
HORTSCIENCE, 2018, 53 (12) : 1872 - 1876
[29] Somatic embryogenesis and plantlet regeneration from leaf and inflorescence explants of arecanut (Areca catechu L.)
Karun, A
Siril, EA
Radha, E
Parthasarathy, VA
CURRENT SCIENCE, 2004, 86 (12): : 1623 - 1628
[30] Chemical composition, antibacterial and antioxidant activities of hydrosols from different parts of Areca catechu L. and Cocos nucifera L.
Shen, Xiaojun
Chen, Weibo
Zheng, Yajun
Lei, Xintao
Tang, Minmin
Wang, Hui
Song, Fei
INDUSTRIAL CROPS AND PRODUCTS, 2017, 96 : 110 - 119

← 1 2 3 4 5 →