Lactate as a regulator of iron homeostasis

被引：1
|
作者：
Anderson, Gregory J. [1 ]
Frazer, David M. [2 ]
机构：
[1] QIMR Berghofer Med Res Inst, Iron Metab Lab, 300 Herston Rd, Brisbane, Qld 4006, Australia
[2] QIMR Berghofer Med Res Inst, Mol Nutr Lab, Brisbane, Qld 4006, Australia
来源：
LIFE METABOLISM | 2023年 / 2卷 / 05期
关键词：
D O I：
10.1093/lifemeta/load033
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The key metabolic intermediate lactate can increase expression of the liver-derived peptide hepcidin, the central regulator of body iron homeostasis. A new paper by Liu et al. shows that lactate achieves this by binding to and activating soluble adenylyl cyclase, thereby increasing cellular cyclic adenosine monophosphate (cAMP) and enhancing signaling through the bone morphogenetic protein (BMP) pathway to modulate hepcidin expression. © 2023 Published by Oxford University Press and JSCR Publishing Ltd.
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页数：4
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