This paper establishes a prediction method for the thermo-mechanical fatigue life of SiC power devices based on electro-thermal-mechanical coupling finite element simulation. The Anand constitutive model is used to describe the cyclic mechanical behavior of sintered silver at high temperature, and the Coffin-Manson equation is used to evaluate the thermo-mechanical fatigue damage of sintered silver. Firstly, a non-contact strain measurement and control technology is developed. Secondly, this paper conducted static shear tests on sintered silver interconnect specimens at different strain rates and temperatures, and found that the shear strength of the material decreases with decreasing shear strain rate and decreases with increasing temperature. Moreover, the material constants of the Anand constitutive model for sintered silver were identified based on the static shear stress-strain curve. Thirdly, cyclic shear tests were conducted on sintered silver interconnect specimens, and finite element simulation of the tests were also conducted. The effectiveness of the simulation was verified by comparing the experimental and simulated stress-strain results. Afterwards, the electro-thermal-mechanical coupling finite element simulation of a SiC power devices under power cycling was conducted, and the key dangerous parts of the device under power cycling were identified, then the stress-strain response history of the key dangerous parts was further extracted. Finally, the Coffin-Manson equation was used to calculate the thermo-mechanical fatigue damage and predict the failure life of SiC power devices. By comparing the experimental and predicted life results, it was found that the prediction error was within a factor of 2, indicating that the established method can provide satisfactory prediction results and provide key technical support for the fatigue life design of SiC power devices.