Electrochemical C3-Fluoroalkoxylation of Quinoxalin-2(1H)-ones with Fluoroalkyl Alcohols for the Synthesis of 3-Fluoroalkoxylated Quinoxalin-2(1H)-ones

被引：0
|
作者：
Liu, Yuan-Yuan [1 ]
Chen, Lu [1 ]
Wang, Ting [1 ]
Wang, Guoqin [1 ]
Zhang, Minmin [2 ]
Jing, Linhai [1 ]
Han, Pan [1 ]
Zhang, Zheng-Bing [1 ]
机构：
[1] China West Normal Univ, Chem Synth & Pollut Control Key Lab Sichuan Prov, Nanchong 637002, Peoples R China
[2] Lunan Pharmaceut Grp Co Ltd, Natl Engn Technol Res Ctr Chiral Pharmaceut, Linyi 276005, Shandong, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 34期
关键词：
electrochemical synthesis; C-H fluoroalkoxylation; radical coupling; quinoxalin-2(1H)-ones; environmental friendliness; AEROBIC C3-H FLUOROALKOXYLATION; C-H FUNCTIONALIZATION; QUINOXALINONE; DERIVATIVES; INHIBITORS; CATALYSIS;
D O I：
10.1002/ejoc.202400628
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report the first electricity-driven and metal-free C(3)-H fluoroalkoxylation of quinoxalin-2(1H)-ones with both alpha-monosubstituted and alpha,alpha-disubstituted fluoroalkyl alcohols. This strategy features the advantages of convenience, mildness, effEctiveness and broad substrate practicality for synthesizing a new type of 3-fluoroalkoxylated quinoxalin-2(1H)-ones.
引用
收藏
页数：6
相关论文
共 50 条
  • [21] Ammonium Persulfate Promotes Trifluoromethylation of Quinoxalin-2(1H)-ones
    Yi, Rongnan
    Liu, Dongxian
    He, Jiangnan
    Zhao, Mingming
    Xu, Xinhua
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 41 (08) : 3285 - 3291
  • [22] Photo-/electrocatalytic functionalization of quinoxalin-2(1H)-ones
    Sun, Kai
    Xiao, Fang
    Yu, Bing
    He, Wei-Min
    CHINESE JOURNAL OF CATALYSIS, 2021, 42 (11) : 1921 - 1943
  • [23] Phenyliodonium Diacetate Mediated Carbotrifluoromethylation of Quinoxalin-2(1H)-ones
    Xue, Wenxuan
    Su, Yingpeng
    Wang, Ke-Hu
    Cao, Lindan
    Feng, Yawei
    Zhang, Weigang
    Huang, Danfeng
    Hu, Yulai
    ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 8 (06) : 887 - 892
  • [24] 3-(α-azidoalkyl)quinoxalin-2(1H)-ones and related alkylquinoxalinyl ketones
    Mamedov V.A.
    Saifina D.F.
    Berdnikov E.A.
    Chemistry of Heterocyclic Compounds, 2007, 43 (04) : 470 - 473
  • [25] Synthesis of Quinoxalin-2(1H)-ones and Hexahydroquinoxalin-2(1H)-ones via Oxidative Amidation-Heterocycloannulation
    Raghunadh, Akula
    Tadiparthi, Krishnaji
    Meruva, Suresh Babu
    Murthy, V. Narayana
    Rao, L. Vaikunta
    Kumar, U. K. Syam
    SYNOPEN, 2020, 04 (03): : 55 - 61
  • [26] Electro-oxidative C-H azolation of quinoxalin-2(1H)-ones
    Niu, Kaikai
    Ding, Ling
    Zhou, Pan
    Hao, Yanke
    Liu, Yuxiu
    Song, Hongjian
    Wang, Qingmin
    GREEN CHEMISTRY, 2021, 23 (09) : 3246 - 3249
  • [27] Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones
    Ling Ding
    Kaikai Niu
    Yuxiu Liu
    Qingmin Wang
    Chinese Chemical Letters, 2022, 33 (08) : 4057 - 4060
  • [28] 3-(α-Chlorobenzyl)quinoxalin-2(1H)-ones as Versatile Reagents for the Synthesis of 3-Benzylquinoxalin-2(1H)-ones and Thiazolo[3,4-a]quinoxalin-4(5H)-ones
    Mamedov, Vakhid A.
    Zhukova, Nataliya A.
    Syakaev, Victor V.
    Beschastnova, Tat'yana N.
    Kadyrova, Milyausha S.
    Isaeva, Anastasiya O.
    Mamedova, Sevil, V
    Gavrilova, Elena L.
    Latypov, Shamil K.
    Sinyashin, Oleg G.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (08) : 2221 - 2234
  • [29] Visible-Light-Mediated C3-H Acetalation of Quinoxalin-2(1H)-ones
    Zhang Mengqi
    Nan Guangming
    Zhao Xiaohui
    Wei Wei
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 42 (12) : 4315 - 4322
  • [30] Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones
    Ding, Ling
    Niu, Kaikai
    Liu, Yuxiu
    Wang, Qingmin
    CHINESE CHEMICAL LETTERS, 2022, 33 (08) : 4057 - 4060
12345