Targeted isolation of lignans from the roots of Anthriscus sylvestris (L.) Hoffm. by small molecule accurate recognition technology

被引：0
|
作者：
Liu, Yan-ling [1 ,2 ]
Cao, Yan-gang [1 ,2 ]
Zheng, Ya-juan [1 ,2 ]
Niu, Ying [1 ,2 ]
Chen, Lan [1 ,2 ]
Chen, Xu [1 ,2 ]
Ma, Xin-yi [1 ,2 ]
Li, Xiang-da [1 ,2 ]
Zheng, Xiao-ke [1 ,2 ,3 ]
Feng, Wei-sheng [1 ,2 ,3 ]
机构：
[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China
[2] Engn & Technol Ctr Chinese Med Dev Henan Prov Chin, Zhengzhou 450046, Peoples R China
[3] Coconstruct Collaborat Innovat Ctr Chinese Med & R, Zhengzhou 450046, Peoples R China
来源：
PHYTOCHEMISTRY | 2025年 / 229卷
关键词：
Anthriscus sylvestris; Apiaceae; Lignans; NMR spectra-guided isolation; Anti-proliferative effect; CONSTITUENTS; DEOXYPODOPHYLLOTOXIN; HYPERTENSION; SEEDS;
D O I：
10.1016/j.phytochem.2024.114293
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Five undescribed lignans (1-5), 1 - 5 ), along with sixteen known lignans (6-21), 6 - 21 ), were isolated from the roots of Anthriscus sylvestris using small molecule accurate recognition technology (SMART). The structures of the isolated compounds were determined by comprehensive spectroscopic analyses, and the absolute configurations of compounds 3 - 5 were elucidated by comparison of their calculated and experimental ECD spectra. Compounds 5 , 14-15,- 15 , 19 , and 21 exhibited significantly inhibitory effects against hypoxia-stimulated abnormal proliferation of pulmonary arterial smooth muscle cells (PASMCs). Moreover, compounds 5 , 14-15,- 15 , 19 , and 21 can significantly restore expression of expression of PASMCs proliferation-related protein, including alpha-SMA, PCNA, P27, and CyclinD3, which are closely related to cell proliferation.
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页数：11
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