How Can Spatial Transcriptomic Profiling Advance Our Understanding of Skin Diseases?

被引：1

作者：

Kumaran, Girishkumar ^{[1
]}

Carroll, Liam ^{[1
]}

Muirhead, Nina ^{[2
]}

Bottomley, Matthew J. ^{[1
]}

机构：

[1] Univ Oxford, Chinese Acad Med Sci Oxford Inst, Nuffield Dept Med, Oxford OX1 2JD, England

[2] Skin Inspect, London, England

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2025年 / 145卷 / 03期

关键词：

Gene expression mapping; Skin tissue transcriptomics; Spatial analysis; Spatial transcriptomics; Transcriptomic profiling; IN-SITU HYBRIDIZATION; SQUAMOUS-CELL CARCINOMA; GENE-EXPRESSION; HIGH-RISK; RNA; TISSUE; ARCHITECTURE; IMMUNITY; CANCER; VISUALIZATION;

D O I：

10.1016/j.jid.2024.07.006

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Spatial transcriptomic (ST) profiling is the mapping of gene expression within cell populations with preservation of positional context and represents an exciting new approach to develop our understanding of local and regional influences upon skin biology in health and disease. With the ability to probe from a few hundred transcripts to the entire transcriptome, multiple ST approaches are now widely available. In this paper, we review the ST field and discuss its application to dermatology. Its potential to advance our understanding of skin biology in health and disease is highlighted through the illustrative examples of 3 research areas: cutaneous aging, tumorigenesis, and psoriasis.

引用

页码：522 / 535

页数：14

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