How Can Spatial Transcriptomic Profiling Advance Our Understanding of Skin Diseases?

被引：1

作者：

Kumaran, Girishkumar ^{[1
]}

Carroll, Liam ^{[1
]}

Muirhead, Nina ^{[2
]}

Bottomley, Matthew J. ^{[1
]}

机构：

[1] Univ Oxford, Chinese Acad Med Sci Oxford Inst, Nuffield Dept Med, Oxford OX1 2JD, England

[2] Skin Inspect, London, England

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2025年 / 145卷 / 03期

关键词：

Gene expression mapping; Skin tissue transcriptomics; Spatial analysis; Spatial transcriptomics; Transcriptomic profiling; IN-SITU HYBRIDIZATION; SQUAMOUS-CELL CARCINOMA; GENE-EXPRESSION; HIGH-RISK; RNA; TISSUE; ARCHITECTURE; IMMUNITY; CANCER; VISUALIZATION;

D O I：

10.1016/j.jid.2024.07.006

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Spatial transcriptomic (ST) profiling is the mapping of gene expression within cell populations with preservation of positional context and represents an exciting new approach to develop our understanding of local and regional influences upon skin biology in health and disease. With the ability to probe from a few hundred transcripts to the entire transcriptome, multiple ST approaches are now widely available. In this paper, we review the ST field and discuss its application to dermatology. Its potential to advance our understanding of skin biology in health and disease is highlighted through the illustrative examples of 3 research areas: cutaneous aging, tumorigenesis, and psoriasis.

引用

页码：522 / 535

页数：14

共 50 条

[1] Spatial replication can best advance our understanding of population responses to climate
Compagnoni, Aldo
Evers, Sanne
Knight, Tiffany
ECOGRAPHY, 2024, 2024 (01)
[2] NORSE/FIRES: how can we advance our understanding of this devastating condition?
Champsas, Dimitrios
Zhang, Xushuo
Rosch, Richard
Ioannidou, Evangelia
Gilmour, Kimberly
Cooray, Gerald
Woodhall, Gavin
Pujar, Suresh
Kaliakatsos, Marios
Wright, Sukhvir K.
FRONTIERS IN NEUROLOGY, 2024, 15
[3] Epidemiology of CF: How registries can be used to advance our understanding of the CF population
Jackson, Abaigeal D.
Goss, Christopher H.
JOURNAL OF CYSTIC FIBROSIS, 2018, 17 (03) : 297 - 305
[4] Cochrane's Linked Data Project: How it Can Advance our Understanding of Surrogate Endpoints
Mavergames, Chris
Beecher, Deirdre
Becker, Lorne A.
Last, A.
Ali, A.
JOURNAL OF LAW MEDICINE & ETHICS, 2019, 47 (03): : 374 - 380
[5] How can connectomics advance our knowledge of psychiatric disorders?
Cocchi, Luca
Zalesky, Andrew
Fontenelle, Leonardo F.
REVISTA BRASILEIRA DE PSIQUIATRIA, 2012, 34 (02) : 131 - 132
[6] Spatial-transcriptomic profiling: a new lens for understanding myelofibrosis pathophysiology
Peroni, Edoardo
Calistri, Elisabetta
Amato, Rosario
Gottardi, Michele
Rosato, Antonio
CELL COMMUNICATION AND SIGNALING, 2024, 22 (01)
[7] Can PET/CT imaging advance our understanding of the neurobiology of schizophrenia?
Vyas, Nora S.
Patel, Neva H.
Nijran, Kuldip S.
Al-Nahhas, Adil
Puri, Basant K.
NUCLEAR MEDICINE COMMUNICATIONS, 2010, 31 (02) : 91 - 93
[8] How can rAAV--synuclein and the fibril -synuclein models advance our understanding of Parkinson's disease?
Volpicelli-Daley, Laura A.
Kirik, Deniz
Stoyka, Lindsay E.
Standaert, David G.
Harms, Ashley S.
JOURNAL OF NEUROCHEMISTRY, 2016, 139 : 131 - 155
[9] How Computational Experiments Can Improve Our Understanding of the Genetic Architecture of Common Human Diseases
Moore, Jason H.
Olson, Randal S.
Schmitt, Peter
Chen, Yong
Manduchi, Elisabetta
ARTIFICIAL LIFE, 2020, 26 (01) : 23 - 37
[10] How Can Family Scholars Advance Understanding of Sleep and Health?
Redline, Susan
FAMILY CONTEXTS OF SLEEP AND HEALTH ACROSS THE LIFE COURSE, 2017, 8 : 177 - 181

← 1 2 3 4 5 →