Understanding the Associations between High-Dose Methotrexate Pharmacokinetics and the Risk of Adverse Events in Children and Adolescents with Down Syndrome Associated High-Risk Acute Lymphoblastic Leukemia

被引:0
|
作者
Westmoreland, Kate D. [1 ,2 ]
Taylor, Zachary L. [3 ,4 ]
Miller, Tamara P. [5 ,6 ]
Chavana, Ashley [7 ]
Rabin, Karen R. [8 ,9 ,10 ]
Brown, Austin L. [11 ]
Bernhardt, Melanie Brooke [12 ]
Schafer, Eric S. [8 ,9 ,10 ]
O'Brien, Maureen M. [13 ,14 ]
Castellino, Sharon M. [5 ,15 ]
Ramsey, Laura B. [3 ,4 ]
机构
[1] Univ North Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA
[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA
[3] Cincinnati Childrens Hosp, Dept Pediat, Div Pediat Hematol Oncol, Med Ctr, Chapel Hill, NC 27599 USA
[4] Cincinnati Childrens Hosp Med Ctr, Canc & Blood Dis Inst, Div Hematol, Cincinnati, OH USA
[5] Childrens Healthcare Atlanta, Aflac Canc & Blood Disorders Ctr, Cincinnati, OH USA
[6] Emory Univ, Childrens Healthcare Atlanta, Sch Med, Atlanta, GA USA
[7] Baylor Coll Med, Houston, TX USA
[8] Baylor Coll Med, Dept Pediat, Div Hematol Oncol, Houston, TX USA
[9] Texas Childrens Hosp, Canc Ctr, Houston, TX USA
[10] Texas Childrens Hosp, Div Pediat Hematol Oncol, Houston, TX USA
[11] Baylor Coll Med, Dept Pediat, Houston, TX USA
[12] St Jude Childrens Res Hosp, Dept Pharm & Pharmaceut Sci, Memphis, TN USA
[13] Colorado Childrens Hosp, Aurora, CO USA
[14] Univ Colorado, Sch Med, Aurora, CO USA
[15] Emory Univ, Sch Med, Dept Pediat, Div Hematol Oncol & Bone Marrow Transplant, Decatur, GA USA
关键词
D O I
10.1182/blood-2024-211870
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1438 / 1439
页数:2
相关论文
共 50 条
  • [1] UNDERSTANDING THE ASSOCIATIONS BETWEEN HIGH-DOSE METHOTREXATE PHARMACOKIN ETICS AND THE RISK OF TOXICITIES IN INFANTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA
    Taylor, Z.
    Miller, T.
    DeGroote, N.
    Board, S.
    Poweleit, E.
    Chavana, A.
    Ambrosino, N.
    Weisnicht, A.
    Brown, A.
    Bernhardt, B.
    Schafer, E.
    O'Brien, M.
    Castellino, S.
    Ramsey, L.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2024, 115 : S45 - S46
  • [2] UNDERSTANDING THE ASSOCIATIONS BETWEEN HIGH-DOSE METHOTREXATE PHARMACOKIN ETICS AND THE RISK OF TOXICITIES IN INFANTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA
    Taylor, Z.
    Miller, T.
    DeGroote, N.
    Board, S.
    Poweleit, E.
    Chavana, A.
    Ambrosino, N.
    Weisnicht, A.
    Brown, A.
    Bernhardt, B.
    Schafer, E.
    O'Brien, M.
    Castellino, S.
    Ramsey, L.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2024, 115 : S70 - S71
  • [4] Myelotoxicity Following High-Dose Methotrexate in Children with Down Syndrome and Acute Lymphoblastic Leukemia
    Bohnstedt, C.
    Levinsen, M.
    Rosthoj, S.
    Zeller, B.
    Taskinen, M.
    Hafsteinsdottir, S.
    Bjorgvinsdottir, H.
    Heymann, M.
    Schmiegelow, K.
    PEDIATRIC BLOOD & CANCER, 2018, 65 : S104 - S104
  • [5] Is hypoalbuminemia a risk factor for high-dose methotrexate toxicity in children with acute lymphoblastic leukemia?
    Barakat, Shaimaa
    Assem, Hala
    Salama, Mostafa
    Mikhael, Neveen
    El Chazli, Yasmine
    JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE, 2022, 34 (01)
  • [6] Is hypoalbuminemia a risk factor for high-dose methotrexate toxicity in children with acute lymphoblastic leukemia?
    Shaimaa Barakat
    Hala Assem
    Mostafa Salama
    Neveen Mikhael
    Yasmine El Chazli
    Journal of the Egyptian National Cancer Institute, 34
  • [7] Pharmacokinetics of High-Dose Methotrexate in Infants Treated for Acute Lymphoblastic Leukemia
    Lonnerholm, Gudmar
    Valsecchi, Maria Grazia
    De Lorenzo, Paola
    Schrappe, Martin
    Hovi, Liisa
    Campbell, Myriam
    Mann, Georg
    Janka-Schaub, Gritta
    Li, Chi-Kong
    Stary, Jan
    Hann, Ian
    Pieters, Rob
    PEDIATRIC BLOOD & CANCER, 2009, 52 (05) : 596 - 601
  • [8] Pharmacokinetics and Pharmacodynamics of High Dose Methotrexate in Children with Acute Lymphoblastic Leukemia and down Syndrome: a Case Cohort Study
    Buitenkamp, T.
    Mathot, R.
    Vulto, A.
    Veerman, A.
    van Wering, E.
    Pieters, R.
    Van Den Heuvel, M.
    Zwaan, Christian M.
    BLOOD, 2008, 112 (11) : 574 - 575
  • [9] Population pharmacokinetics of high-dose methotrexate in children with acute lymphoblastic leukaemia
    Aumente, Dolores
    Buelga, Dolores Santos
    Lukas, John C.
    Gomez, Pedro
    Torres, Antonio
    Garcia, Maria Jose
    CLINICAL PHARMACOKINETICS, 2006, 45 (12) : 1227 - 1238
  • [10] Population Pharmacokinetics of High-Dose Methotrexate in Children with Acute Lymphoblastic Leukaemia
    Dolores Aumente
    Dolores Santos Buelga
    John C. Lukas
    Pedro Gomez
    Antonio Torres
    Maria José García
    Clinical Pharmacokinetics, 2006, 45 : 1227 - 1238