Bidirectional relationship between diabetes mellitus and depression: Mechanisms and epidemiology

被引：0

作者：

Liu, Yun ^{[1
]}

Huang, Shi-Yan ^{[2
]}

Liu, De-Le ^{[3
]}

Zeng, Xin-Xing ^{[2
]}

Pan, Xiao-Rui ^{[2
]}

Peng, Jie ^{[2
]}

机构：

[1] Nanchang Univ, Jiangxi Mental Hosp, Dept Psychiat, Affiliated Mental Hosp, 43 Shangfang Rd, Nanchang 330029, Peoples R China

[2] Nanchang Univ, Affiliated Hosp 2, Clin Med Coll 2, Jiangxi Med Coll, Nanchang 330006, Jiangxi, Peoples R China

[3] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Dept Psychosomat Med, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China

来源：

WORLD JOURNAL OF PSYCHIATRY | 2024年 / 14卷 / 10期

关键词：

Diabetes; Depression; Mechanisms; Epidemiology; Bidirectional relationship; TYPE-2; DEFINITION; EXERCISE;

D O I：

10.5498/wjp.v14.i10.1429

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Diabetes mellitus and depression exhibit a complex bidirectional relationship that profoundly impacts patient health and quality of life. This review explores the physiological mechanisms, including inflammation, oxidative stress, and neuroendocrine dysregulation, that link these conditions. Psychosocial factors such as social support and lifestyle choices also contribute significantly. Epidemiological insights reveal a higher prevalence of depression among diabetics and an increased risk of diabetes in depressed individuals, influenced by demographic variables. Integrated management strategies combining mental health assessments and personalized treatments are essential. Future research should focus on longitudinal and multi-omics studies to deepen understanding and improve therapeutic outcomes.

引用

页数：9

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