Gold-Catalyzed Cope Rearrangements

Over decades, Cope rearrangements have attracted significant research interest in the field of synthetic organic chemistry relying on their ability to undergo stereoselective structural reorganization. Despite substantial progress, the development of this field remained confined to the use of parent 1,5-hexadienes. Against the backdrop of classical Cope reaction, we report the utilization of unconventional 1,6-heptadienes to develop the arylative Cope rearrangement by harnessing the interplay between the pi-activation and cross-coupling reactivity mode of gold complexes. Several mechanistic investigations such as P-31 NMR study, HRMS analysis, cross-over experiment, control experiments were performed to support the proposed cyclization-induced [3,3]-rearrangement mechanism in arylative Cope reaction. 1 Gold-Catalyzed Cope Rearrangements 2 Gold-Catalyzed Arylative Cope Rearrangement 3 Conclusion