Chronic Use of Proton Pump Inhibitors Is Associated With Reduced 30-Day Mortality From Acute Pancreatitis

被引：0
|
作者：
Fischman, Maya [1 ]
Elias, Adi [2 ]
Klein, Amir [3 ,4 ]
Cohen, Yaron [1 ]
Azzam, Zaher S. [4 ,5 ]
Ghersin, Itai [3 ,4 ,6 ]
机构：
[1] Hebrew Univ Jerusalem, Fac Med, Dept Mil Med, Jerusalem, Israel
[2] Univ Calif Los Angeles, Div Cardiol, Los Angeles, CA USA
[3] Rambam Hlth Care Campus, Dept Gastroenterol, Haifa, Israel
[4] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel
[5] Rambam Hlth Care Campus, Div Med, Haifa, Israel
[6] St Marks Hosp, Inflammatory Bowel Dis Unit, London, England
来源：
ALIMENTARY PHARMACOLOGY & THERAPEUTICS | 2025年
关键词：
D O I：
10.1111/apt.18523
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Proton pump inhibitors (PPIs) decrease pancreatic exocrine secretions. There has been interest in the impact of their short-term in-hospital administration on acute pancreatitis (AP) outcomes. It is unknown whether long-term use affects AP outcomes. We investigated the association between chronic PPI use and short-term AP outcomes. We included all (2308) patients admitted with a primary diagnosis of AP (625 on chronic PPI use) between January 2008 and June 2021 and evaluated any association between chronic PPI use and 30-day all-cause mortality by univariate logistic regression. Compared to non-users, patients on chronic PPIs were older (p < 0.001) and had a higher Charlson Comorbidity Index score (p < 0.001). Mortality rates at 30 days were 1.5% in chronic PPI users and 4.6% in non-users (OR 0.33; 95% CI, 0.16-0.6; p < 0.001).
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