Safety, tolerability and weight reduction findings of oral amycretin: a novel amylin and glucagon-like peptide-1 receptor co-agonist, in a first-in-human study

被引：0
|
作者：
Gasiorek, A. [1 ]
Heydorn, A. [1 ]
Kirkeby, K. [1 ]
Key, C. [2 ]
Toubro, S. [1 ]
Schefe, L. H. [1 ]
Dahl, K. [1 ]
Hjerpsted, J. B. [1 ]
Vegge, A. [1 ]
机构：
[1] Novo Nordisk AS, Malov, Denmark
[2] ICON Plc, San Antonio Clin Res Unit, San Antonio, TX USA
来源：
DIABETOLOGIA | 2024年 / 67卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
74
引用
收藏
页码：S42 / S43
页数：2
相关论文
共 50 条
  • [31] Is it Time to Expand Glucagon-like Peptide-1 Receptor Agonist Use for Weight Loss in Patients Without Diabetes?
    Wendy H. Updike
    Olivia Pane
    Rachel Franks
    Faizah Saber
    Farah Abdeen
    Derek D. Balazy
    Nicholas W. Carris
    Drugs, 2021, 81 : 881 - 893
  • [32] Is it Time to Expand Glucagon-like Peptide-1 Receptor Agonist Use for Weight Loss in Patients Without Diabetes?
    Updike, Wendy H.
    Pane, Olivia
    Franks, Rachel
    Saber, Faizah
    Abdeen, Farah
    Balazy, Derek D.
    Carris, Nicholas W.
    DRUGS, 2021, 81 (08) : 881 - 893
  • [33] Adaptive infusion of a glucagon-like peptide-1/glucagon receptor co-agonist G3215, in adults with overweight or obesity: Results from a phase 1 randomized clinical trial
    Hope, David C. D.
    Ansari, Saleem
    Choudhury, Sirazum
    Alexiadou, Kleopatra
    Tabbakh, Yasmin
    Ilesanmi, Ibiyemi
    Lazarus, Katharine
    Davies, Iona
    Jimenez-Pacheco, Lara
    Yang, Wei
    Ball, Laura-Jayne
    Malviya, Reshma
    Reglinska, Beata
    Khoo, Bernard
    Minnion, James
    Bloom, Stephen R.
    Tan, Tricia M. -M.
    DIABETES OBESITY & METABOLISM, 2024, 26 (04): : 1479 - 1491
  • [34] A randomized Phase I study of the safety, tolerability, pharmacokinetics and pharmacodynamics of BI 456906, a dual glucagon receptor/glucagon-like peptide-1 receptor agonist, in healthy Japanese men with overweight/obesity
    Yazawa, Rie
    Ishida, Masahiro
    Balavarca, Yesilda
    Hennige, Anita M.
    DIABETES OBESITY & METABOLISM, 2023, 25 (07): : 1973 - 1984
  • [35] Case Series: Exposure to Glucagon-like Peptide-1 Receptor Agonist in the First Trimester of Pregnancy in Two Siblings
    Dogan, Serife Ezgi
    Kuskonmaz, Serife Mehlika
    Koc, Goenuel
    Aypar, Ebru
    Culha, Cavit
    ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, 2024, 24 (10) : 1237 - 1239
  • [36] Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets
    Sloop, Kyle W.
    Willard, Francis S.
    Brenner, Martin B.
    Ficorilli, James
    Valasek, Kathleen
    Showalter, Aaron D.
    Farb, Thomas B.
    Cao, Julia X. C.
    Cox, Amy L.
    Michael, M. Dodson
    Sanfeliciano, Sonia Maria Gutierrez
    Tebbe, Mark J.
    Coghlan, Michael J.
    DIABETES, 2010, 59 (12) : 3099 - 3107
  • [37] Stimulation of Insulin Secretion by a Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist in Rodent and Human Islets.
    Sloop, K. W.
    Willard, F. S.
    Brenner, M. B.
    Ficorilli, J.
    Valasek, K.
    Showalter, A. D.
    Farb, T.
    Cao, J. X. C.
    Tebbe, M. J.
    Coghlan, M. J.
    ENDOCRINE REVIEWS, 2010, 31 (03)
  • [38] Central Activation and Weight-Lowering Actions of AC164209, a Peptide Hybrid Linking a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist and an Amylin Mimetic
    Mack, Christine
    Wilson, Julie
    Gu, Guibao
    Cole, Rebecca
    Roland, Barb
    Vu, Calvin
    Soares, Christopher
    Sun, Chengzao
    Trevaskis, James
    Ghosh, Soumitra
    Parkes, David
    Forood, Bruce
    OBESITY, 2008, 16 : S189 - S190
  • [39] Novel glucagon-like peptide-1 receptor agonist regulates energy metabolism through suppressing hepatic gluconeogenesis
    Liu, Wenjuan
    Liu, Rui
    Wen, Xiaoyan
    Wang, Qinghua
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2018, 34
  • [40] Glucagon-like peptide-1 receptor agonist therapy effects on glycemic control and weight in a primary care clinic population
    Palecek, Eric J.
    Kimzey, Margaret M.
    Zhang, Jingwen
    Marsden, Justin
    Bays, Chloe
    Moran, William P.
    Mauldin, Patrick D.
    Schreiner, Andrew D.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2024, 72 (08) : 911 - 919
12345