Biosynthesis of the C-Glycosylated Depside Arenicolin B

被引：0

作者：

Johnson, Colin W. ^{[1
]}

Nuniz, Lorraine ^{[1
]}

Perlatti, Bruno ^{[1
,2
,3
]}

Bills, Gerald F. ^{[2
,4
]}

Tang, Yi ^{[1
,5
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Univ Texas, Brown Fdn Inst Mol Med, Texas Therapeut Inst, Hlth Sci Ctr Houston, Houston, TX 77054 USA

[3] Hexagon Bio, Menlo Pk, CA 94025 USA

[4] Rutgers State Univ, Dept Plant Biol, New Brunswick, NJ 08901 USA

[5] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA

来源：

CHEMBIOCHEM | 2025年

关键词：

depside natural product; <italic>C</italic>-glycosyltransferase; glycosylated natural product; natural product biosynthesis; polyketide synthase; THIELAVIN-A; INHIBITORS;

D O I：

10.1002/cbic.202500003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We uncovered the biosynthetic pathway of the C-glycosylated depside arenicolin B from Phialomyces arenicola through genome mining, heterologous reconstitution and biochemical characterization. The biosynthetic gene cluster (BGC) of arenicolin B is comprised of a HRPKS, a NRPKS, and a C-glycosyltransferase. Through biochemical dissection and evaluation, we demonstrate the NRPKS thioesterase (TE) domain catalyses depside formation.

引用

页数：6

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