Synthesis of 2,3,5-trisubstituted 1H-pyrroles via formal [3+2] cycloaddition of 1-arylpropynes and nitriles and their antiproliferative activities

被引：0
|
作者：
He, Dandan [1 ,2 ,3 ]
Li, Ling [1 ,2 ,3 ]
Wen, Xiong [1 ,2 ,3 ]
Yin, Luxiang [1 ,2 ,3 ]
Li, Jue [1 ,2 ,3 ]
Wu, Sha [1 ,2 ,3 ]
Li, Huili [1 ,2 ,3 ]
Jiang, Fei [1 ,2 ,3 ]
Shen, Xiangchun [1 ,2 ,3 ]
机构：
[1] Guizhou Med Univ, Minist Educ, State Key Lab Funct & Applicat Med Plants, Key Lab Endem & Ethn Dis, 6 Ankang Ave & Guian New Dist, Guiyang 561113, Guizhou, Peoples R China
[2] Guizhou Med Univ, High Efficacy Applicat Nat Med Resources Engn Ctr, Key Lab Optimal Utilizat Nat Med Resources, 6 Ankang Ave & Guian New Dist, Guiyang 561113, Guizhou, Peoples R China
[3] Guizhou Med Univ, High Educ Key Lab Guizhou Prov Nat Med Pharmacol, 6 Ankang Ave & Guian New Dist, Guiyang 561113, Guizhou, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2025年 / 12卷 / 04期
基金：
中国国家自然科学基金;
关键词：
ONE-POT SYNTHESIS; H BOND ADDITION; TETRASUBSTITUTED PYRROLES; REGIOSELECTIVE SYNTHESIS; DERIVATIVES; 2H-AZIRINES; ACCESS;
D O I：
10.1039/d4qo01999g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A straightforward approach for the assembly of 2,3,5-trisubstituted 1H-pyrroles via a base-mediated [3 + 2] cycloaddition of 1-arylpropynes with nitriles has been reported through alkali metal salt-promoted C(sp3)-H functionalization. This reaction features a transition metal-free catalyst, facile starting materials and a wide substrate scope. Moreover, the biological evaluation revealed that these pyrrole products exhibit antiproliferative activities against MDA-MB-231, SGC-7901, and HCT-116 cells, which provides potential applications in pharmaceutical chemistry.
引用
收藏
页码：1150 / 1155
页数：6
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