Recent emerging trends in dendrimer research: Electrochemical sensors and their multifaceted applications in biomedical fields or healthcare

Dendrimers enhance the selectivity and sensitivity of sensors through their synthetic, highly branched, threedimensional structures and large surface area. This unique architecture enables precise functionalization with various recognition elements, significantly improving the specificity and sensitivity of electrochemical sensors for detecting disease markers, biomolecules, and environmental pollutants. Dendrimer-based electrochemical sensors offer promising advancements in healthcare, such as detecting biomarkers for heart disease, monitoring blood glucose levels, and sensitively determining cancer-related proteins. Additionally, incorporating metals and conductive polymers into dendrimer nanocomposites can further enhance sensor performance. This review article provides a detailed overview of dendrimer's history, structure, properties, electrochemical properties, and synthesis methods. Particular attention has been paid to recent developments in the applications of dendrimers including electrochemical sensors, drug delivery, gene therapy and bioimaging. Recent progress in various applications of dendrimer-based electrochemical sensors developed over the last seven years, focusing on their healthcare applications and discussing the primary goals and challenges that will shape future research in this field, is also critically analyzed. These advances in dendrimer technology hold great potential for the development of novel therapeutics and expanded applications in sensor design.