Navigating the mutation maze: An oncogenic driver's guide to macrophage reprogramming

被引：0

作者：

Li, Ziyi ^{[1
]}

Sharma, Ankur ^{[1
,2
]}

机构：

[1] Garvan Inst Med Res, Translat Genom Program, 384 Victoria St, Darlinghurst, NSW 2010, Australia

[2] Univ New South Wales, Fac Med & Hlth, Sch Clin Med, Kensington, NSW 2033, Australia

来源：

IMMUNITY | 2024年 / 57卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.immuni.2024.10.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms by which oncogenic mutations and anatomical locations work together to influence the immune environment within tumors are not well understood. In this issue of Immunity, Ross et al. show that H3.3K27M diffuse midline gliomas (DMGs) are enriched with disease-associated myeloid cells (DAMs). Myeloid-targeted strategies reprogram DAMs to a homeostatic state, reduce myeloid infiltration into tumors, and prolong survival.

引用

页码：2489 / 2491

页数：3

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