Methodology to Control the Regioselective Installation of a Carboxylic Acid for the Synthesis of 2,3-Diarylpropionic Acids

被引：0

作者：

Hamilton, Mason D. ^{[1
]}

Perrone, Trina M. ^{[1
]}

Popp, Brian V. ^{[1
]}

机构：

[1] West Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26505 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2025年 / 367卷 / 04期

基金：

美国国家科学基金会;

关键词：

C-C bond formation; Organoboron; Carboxylation; Palladium catalysis; Regioselectivity; ALKENES; HYDROCARBOXYLATION; RECEPTOR;

D O I：

10.1002/adsc.202400952

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A stepwise copper-catalyzed boracarboxylation then palladium-catalyzed Suzuki-Miyaura cross-coupling methodology was developed to access 2,3-diarylpropionic acid derivatives regioselectively by pre-setting the position of the carboxylic acid in the boracarboxylation reaction. This method provides access to a wide range of aryl and heteroaryl products in up to 80% isolated yield. Pharmaceutical potential was demonstrated by synthesizing a glucagon receptor antagonist drug in three steps (31% overall yield) from commercially available 4-tert-butylstyrene.

引用

页数：6

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