Platelet-rich plasma combined with isometric quadriceps contraction regulates autophagy in chondrocytes via the PI3K/AKT/mTOR pathway to promote cartilage repair in knee osteoarthritis

被引：1
|
作者：
Cheng, Liang [1 ,2 ,3 ]
Chang, Shuwan [1 ]
Tan, Yajun [4 ]
He, Benxiang [2 ]
机构：
[1] Chengdu Sport Univ, Sch Sports Med & Hlth, Chengdu, Peoples R China
[2] Sichuan Acad Chinese Med Sci, Chengdu, Peoples R China
[3] Sichuan Sports Coll, Human Movement Sci, Chengdu, Peoples R China
[4] Chengdu Sport Univ, Affiliated Sport Hosp, Chengdu, Peoples R China
来源：
REGENERATIVE THERAPY | 2025年 / 28卷
关键词：
Platelet-rich plasm; Isometric contraction of quadricep; Autophagy; PI3K/AKT/MTOR; Knee Osteoarthritis; PATHOGENESIS; APOPTOSIS; EXERCISES;
D O I：
10.1016/j.reth.2024.11.013
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
引用
收藏
页码：81 / 89
页数：9
相关论文
共 50 条
  • [31] bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway
    Zhou-Guang Wang
    Yue Wang
    Yan Huang
    Qin Lu
    Lei Zheng
    Dong Hu
    Wen-Ke Feng
    Yan-Long Liu
    Kang-Ting Ji
    Hong-Yu Zhang
    Xiao-Bing Fu
    Xiao-Kun Li
    Mao-Ping Chu
    Jian Xiao
    Scientific Reports, 5
  • [32] miR-21 regulates autophagy and apoptosis of ectopic endometrial stromal cells of adenomyosis via PI3K/ AKT/ mTOR pathway
    Jia, Jin-Jin
    Lai, Hui-jie
    Sun, Bo-Wen
    Lu, Jie
    Zeng, Yu-Yan
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [33] Emodin Promotes Peripheral Nerve Repair by Modulating Inflammasome Activation Through Autophagy via the EGFR/PI3K/AKT/mTOR Pathway
    Long, Zhengyang
    Huang, Yixun
    Lin, Tao
    Xiao, Shanying
    Chen, Kaiye
    Ying, Jiahao
    Wang, Ke
    Zhang, Zhe
    Wu, Long
    PHYTOTHERAPY RESEARCH, 2025,
  • [34] 17β-ESTRADIOL PROMOTES CELL PROLIFERATION IN RAT OSTEOARTHRITIS MODEL CHONDROCYTES VIA PI3K/AKT PATHWAY
    Huang, Jia Gu
    Xia, Chun
    Zheng, Xin Peng
    Yi, Ting Ting
    Wang, Xiao Yong
    Song, Gang
    Zhang, Bing
    CELLULAR & MOLECULAR BIOLOGY LETTERS, 2011, 16 (04) : 564 - 575
  • [35] 17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway
    Jia Gu Huang
    Chun Xia
    Xin Peng Zheng
    Ting Ting Yi
    Xiao Yong Wang
    Gang Song
    Bing Zhang
    Cellular & Molecular Biology Letters, 2011, 16
  • [36] MTHFD1 Regulates Autophagy to Promote Growth and Metastasis in Colorectal Cancer via the PI3K-AKT-mTOR Signaling Pathway
    Li, Zhihao
    Ke, Haoxian
    Cai, Jiawei
    Ye, Shubiao
    Huang, Junfeng
    Zhang, Chi
    Yuan, Ming
    Lan, Ping
    Wu, Xianrui
    CANCER MEDICINE, 2024, 13 (22):
  • [37] Oxidative stress induced by combined glyphosate and TBBPA exposure promotes gill autophagy and inflammation via the PI3K/AKT/ mTOR pathway
    Li, Mingyue
    Lou, Shuang
    Chen, Kai
    Dong, Yuting
    Wang, Shize
    Yu, Tingting
    Deng, Xinrui
    Li, Shu
    FISH & SHELLFISH IMMUNOLOGY, 2025, 160
  • [38] Adipose stem cell exosomes promote mitochondrial autophagy through the PI3K/AKT/mTOR pathway to alleviate keloids
    Liu, Chang
    Khairullina, Liliia
    Qin, Youyou
    Zhang, Yingbo
    Xiao, Zhibo
    STEM CELL RESEARCH & THERAPY, 2024, 15 (01)
  • [39] Silencing UHRF1 enhances cell autophagy to prevent articular chondrocytes from apoptosis in osteoarthritis through PI3K/AKT/mTOR signaling pathway
    Shi, Xiaojuan
    Han, Lei
    Sun, Tianshu
    Zhang, Feng
    Ji, Shiying
    Zhang, Min
    Wang, Xiaoqing
    Yang, Weihong
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 529 (04) : 1018 - 1024
  • [40] Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway
    Duan, Hong
    Li, Han
    Liu, Tianyi
    Chen, Yuan
    Luo, Mengmeng
    Shi, Ying
    Zhou, Jing
    Rashed, Marwan M. A.
    Zhai, Kefeng
    Li, Lili
    Wei, Zhaojun
    ACS OMEGA, 2024, 9 (30): : 32920 - 32930
12345