Identification of a seven-gene prognostic model for renal cell carcinoma associated with CD8+T lymphocyte cell

被引:0
|
作者
Liu, Jingbang [1 ]
Jiang, Tao [1 ]
机构
[1] Dalian Med Univ, Affiliated Hosp 2, Dept Urol, Dalian 116000, Liaoning, Peoples R China
基金
中国国家自然科学基金;
关键词
bioinformatics; CD8+T lymphocytes; renal cell carcinoma; tumor adaptive immunity; tumor microenvironment; INFILTRATION;
D O I
10.1097/MD.0000000000039938
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
CD8+ T lymphocytes are important elements of the tumor microenvironment, hence their involvement in the development and progression of tumors is complex. Data on the precise tumor-infiltrating lymphocytes gene signature in renal cell carcinoma (RCC) remain limited. Therefore, this study created a tumor-infiltrating lymphocytes-related predictive model for patients with RCC using data from The Cancer Genome Atlas. The most important genes associated with CD8 + T lymphocytes were identified using weighted gene co-expression network analysis. Functional categories of important genes were revealed using gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes signaling pathway analyses. A CD8 + T lymphocyte-related prognostic model with 7 important genes was simultaneously created using the least absolute shrinkage and selection operator, univariate and multivariate Cox regressions, and the 7 genes were expressed particularly in CD8 + T lymphocytes according to single-cell sequencing data obtained from the Gene Expression Omnibus. This study identified a seven-gene prognostic model associated with CD8 + T lymphocytes that may significantly influence risk stratification in patients with RCC. The genes included in the model are apolipoprotein B mRNA editing catalytic polypeptide 3G, CD3 gamma, eomesodermin, protein tyrosine phosphatase, non-receptor type 7, signal regulatory protein gamma, Fas ligand, and T-cell immunoreceptor with Ig and ITIM domains.
引用
收藏
页数:9
相关论文
共 50 条
  • [21] Full maturation of CD8+T cell
    Tsumiyama, Ken
    Hashiramoto, Akira
    Shiozawa, Shunichi
    ARTHRITIS AND RHEUMATISM, 2008, 58 (09): : S705 - S706
  • [22] Identification of biomarkers related to CD8+ T cell infiltration with gene co-expression network in clear cell renal cell carcinoma
    Lin, Jiaxing
    Yu, Meng
    Xu, Xiao
    Wang, Yutao
    Xing, Haotian
    An, Jun
    Yang, Jieping
    Tang, Chaozhi
    Sun, Dan
    Zhu, Yuyan
    AGING-US, 2020, 12 (04): : 3694 - 3712
  • [23] Identification of ST3GAL5 as a prognostic biomarker correlating with CD8+ T cell exhaustion in clear cell renal cell carcinoma
    Liu, Jiakuan
    Li, Meiqian
    Wu, Jiajun
    Qi, Qi
    Li, Yang
    Wang, Simei
    Liang, Shengjie
    Zhang, Yuqing
    Zhu, Zhitao
    Huang, Ruimin
    Yan, Jun
    Zhu, Rujian
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [24] Identification and validation of a seven-gene prognostic marker in colon cancer based on single-cell transcriptome analysis
    Zhou, Yang
    Guo, Yang
    Wang, Yuanhe
    IET SYSTEMS BIOLOGY, 2022, 16 (02) : 72 - 83
  • [25] LINC00887 Fosters Development of Clear Cell Renal Cell Carcinoma via Inhibiting CD8+T Cell Immune Infiltration
    Wu, Jinfeng
    Lin, Rongcheng
    Zhang, Lei
    Wei, Yongbao
    Zhang, Ruochen
    Cai, Wanghai
    Hu, Weilie
    COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2022, 2022
  • [26] Gene expression profiling of clear cell renal cell carcinoma: Gene identification and prognostic classification
    Takahashi, M
    Rhodes, DR
    Furge, KA
    Kanayamat, H
    Kagawa, S
    Haab, BB
    Teh, BT
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) : 9754 - 9759
  • [27] Prognostic value of peripheral blood T lymphocyte subsets in clear cell renal cell carcinoma
    Zhou, Yihong
    Jiang, Doug
    Chu, Xi
    Cheng, Wenjie
    Huang, Shuchang
    Wang, Jinhua
    Zhang, Hao
    Liu, Min
    Tang, Yuxin
    Dai, Yingbo
    TRANSLATIONAL ANDROLOGY AND UROLOGY, 2021, 10 (01)
  • [28] Accumulation of CD45RO+CD8+T cells is a diagnostic and prognostic biomarker for clear cell renal cell carcinoma
    Wu, Ke
    Zheng, Xinyi
    Yao, Zhixian
    Zheng, Zhong
    Huang, Wenjie
    Mu, Xingyu
    Sun, Feng
    Liu, Zhihong
    Zheng, Junhua
    AGING-US, 2021, 13 (10): : 14304 - 14321
  • [29] Identification of CD8+T cell host factors involved in HIV control
    Gaiha, G.
    McKim, K.
    Woods, M.
    Lichterfeld, M.
    Brass, A.
    Wallker, B.
    RETROVIROLOGY, 2012, 9
  • [30] Tumor Infiltrating Lymphocytes and CD8+T Cell Subsets as Prognostic Markers in Patients with Surgically Treated Laryngeal Squamous Cell Carcinoma
    Chatzopoulos, Kyriakos
    Kotoula, Vassiliki
    Manoussou, Kyriaki
    Markou, Konstantinos
    Vlachtsis, Konstantinos
    Angouridakis, Nikolaos
    Nikolaou, Angelos
    Vassilakopoulou, Maria
    Psyrri, Amanda
    Fountzilas, Georgios
    HEAD & NECK PATHOLOGY, 2020, 14 (03): : 689 - 700