SETD2 LOSS CONTRIBUTES TO CHRONIC MYELOID LEUKEMIA PROGRESSION AFFECTING DNA INTEGRITY AND EPIGENETIC LANDSCAPE

被引：0
|
作者：
Mancini, M. [1 ]
De Santis, S. [2 ]
Monaldi, C. [2 ]
Bruno, S. [2 ]
Taccini, A. C. [2 ]
Castagnetti, F. [2 ]
Gugliotta, G. [1 ]
Iurlo, A. [3 ]
Cerrano, M. [4 ]
Galimberti, S. [5 ]
Balducci, S. [5 ]
Cavo, M. [1 ,2 ]
Soverini, S. [1 ]
机构：
[1] Univ Bologna, IRCCS Azienda Osped, Ist Ematol Seragnoli, Bologna, Italy
[2] Univ Bologna, Dipartimento Sci Med Chirurg, Bologna, Italy
[3] Fdn IRCCS Ca Granda Osped Policlin, UO Oncoematol, Milan, Italy
[4] AOU Citta Salute Sci Torino, Turin, Italy
[5] Univ Pisa, Clin & Expt Med, Hematol, Pisa, Italy
来源：
HAEMATOLOGICA | 2024年 / 109卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
P020
引用
收藏
页码：67 / 67
页数：1
相关论文
共 50 条
  • [31] Epigenetic inactivation of DLX4 is associated with disease progression in chronic myeloid leukemia
    Zhou, Jing-Dong
    Wang, Yu-Xin
    Zhang, Ting-Juan
    Yang, Dong-qin
    Yao, Dong-Ming
    Guo, Hong
    Yang, Lei
    Ma, Ji-Chun
    Wen, Xiang-Mei
    Yang, Jing
    Lin, Jiang
    Qian, Jun
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 463 (04) : 1250 - 1256
  • [32] ReSETting SETD2/H3K36Me3 Deficiency as a New Therapeutic Strategy in Blast Crisis Chronic Myeloid Leukemia Patients
    De Santis, Sara
    Mancini, Manuela
    Monaldi, Cecilia
    Martelli, Margherita
    Castagnetti, Fausto
    Gugliotta, Gabriele
    Rosti, Gianantonio
    Dan, Elisa
    Sinigaglia, Barbara
    Iurlo, Alessandra
    Abruzzese, Elisabetta
    Salvucci, Marzia
    Pregno, Patrizia
    Gozzini, Antonella
    Crugnola, Monica
    Albano, Francesco
    Bonifacio, Massimiliano
    Calistri, Elisabetta
    Tiribelli, Mario
    Binotto, Gianni
    Imovilli, Annalisa
    Trabacchi, Elena
    Galimberti, Sara
    Barate, Claudia
    Baccarani, Michele
    Martinelli, Giovanni
    Cavo, Michele
    Soverini, Simona
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2020, 20 : S236 - S237
  • [33] Acute myeloid leukemia with NPM1, IDH2, and SETD2 mutations mimicking acute promyelocytic leukemia: A case report and literature review
    Chen, Xiang-Lei
    Zeng, Shan-Shan
    MEDICINE, 2024, 103 (42)
  • [34] Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way
    Mancini, Manuela
    De Santis, Sara
    Monaldi, Cecilia
    Bavaro, Luana
    Martelli, Margherita
    Gugliotta, Gabriele
    Castagnetti, Fausto
    Rosti, Gianantonio
    Fontana, Maria Chiara
    Bruno, Samantha
    Dan, Elisa
    Sinigaglia, Barbara
    Iurlo, Alessandra
    Orofino, Nicola
    Abruzzese, Elisabetta
    Salvucci, Marzia
    Pregno, Patrizia
    Gozzini, Antonella
    Crugnola, Monica
    Albano, Francesco
    Bonifacio, Massimiliano
    Calistri, Elisabetta
    Tiribelli, Mario
    Binotto, Gianni
    Imovilli, Annalisa
    Trabacchi, Elena
    Galimberti, Sara
    Barate, Claudia
    Tenti, Elena
    Baccarani, Michele
    Martinelli, Giovanni
    Cavo, Michele
    Soverini, Simona
    BLOOD, 2019, 134
  • [35] Prevention of progression in chronic myeloid leukemia by altering DNA methylation with a pyridoxine analogue
    Sastry, PSRK
    MEDICAL HYPOTHESES, 1999, 53 (06) : 488 - 489
  • [36] Genetic polymorphisms of DNA repair genes in the origin and progression of chronic myeloid leukemia
    Gorre, Manjula
    Mohandas, Prajitha Edathara
    Kagita, Sailaja
    Cingeetham, Anuradha
    Vuree, Sugunakar
    Annamaneni, Sandhya
    Digumarti, Raghunadharao
    Satti, Vishnupriya
    CANCER RESEARCH, 2015, 75
  • [37] SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair
    N Kanu
    E Grönroos
    P Martinez
    R A Burrell
    X Yi Goh
    J Bartkova
    A Maya-Mendoza
    M Mistrík
    A J Rowan
    H Patel
    A Rabinowitz
    P East
    G Wilson
    C R Santos
    N McGranahan
    S Gulati
    M Gerlinger
    N J Birkbak
    T Joshi
    L B Alexandrov
    M R Stratton
    T Powles
    N Matthews
    P A Bates
    A Stewart
    Z Szallasi
    J Larkin
    J Bartek
    C Swanton
    Oncogene, 2015, 34 : 5699 - 5708
  • [38] Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway
    Ma, Chunxiao
    Liu, Min
    Feng, Wenxin
    Rao, Hanyu
    Zhang, Wei
    Liu, Changwei
    Xu, Yue
    Wang, Ziyi
    Teng, Yan
    Yang, Xiao
    Ni, Li
    Xu, Jin
    Gao, Wei-Qiang
    Lu, Bing
    Li, Li
    CLINICAL AND TRANSLATIONAL MEDICINE, 2023, 13 (11):
  • [39] SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair
    Kanu, N.
    Groenroos, E.
    Martinez, P.
    Burrell, R. A.
    Goh, X. Yi
    Bartkova, J.
    Maya-Mendoza, A.
    Mistrik, M.
    Rowan, A. J.
    Patel, H.
    Rabinowitz, A.
    East, P.
    Wilson, G.
    Santos, C. R.
    McGranahan, N.
    Gulati, S.
    Gerlinger, M.
    Birkbak, N. J.
    Joshi, T.
    Alexandrov, L. B.
    Stratton, M. R.
    Powles, T.
    Matthews, N.
    Bates, P. A.
    Stewart, A.
    Szallasi, Z.
    Larkin, J.
    Bartek, J.
    Swanton, C.
    ONCOGENE, 2015, 34 (46) : 5699 - 5708
  • [40] Research on epigenetic mechanism of SFRP2 in advanced chronic myeloid leukemia
    Li, Ziye
    Luo, Jianmin
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 501 (01) : 64 - 72
12345