The ever-increasing number and variety of exotic pets have imposed an inevitable challenge to veterinary profession, expecting the veterinarians to safeguard health and welfare of both animals and humans, as well as the environment. This study investigated perception of last-year veterinary students concerning welfare issues, health and safety of humans and other animals, along with environmental protection associated with keeping exotic pet mammals, and their self-reported knowledge of these pets. The sixth-year veterinary students in Croatia were surveyed in the 2019-2020 academic year, with a response rate of 82% (95 students). The questionnaire was focused on rodents, rabbits, and ferrets. Students generally agreed on the issues related to the welfare of these pets, with their responses yielding no significant between-mammal differences. There were no significant differences among particular mammals either in the issues other than animal welfare, with which they did not agree or were uncertain. Students considered themselves to have appropriate knowledge about nutrition, housing, health and behavior of these pets. Previous experience with exotic pets showed a substantial association with student perception of these animals. Study results suggest an adequate student perception of exotic pet mammal welfare, along with their appropriate self-reported knowledge of these pets, however, veterinarians-to-be are expected to think twice about the implications that exotic pet animals may have for humans, other animals, and eventually for the environment. Therefore, there is a need of additional student education in the field through intensification of their interaction with these animals, which especially refers to human health issues associated with these animals.