Tailoring Design of Microneedles for Drug Delivery and Biosensing

被引：0

作者：

Lin, Yuexi ^{[1
,2
]}

Dervisevic, Muamer ^{[1
,2
]}

Yoh, Hao Zhe ^{[1
]}

Guo, Keying ^{[1
,3
,4
]}

Voelcker, Nicolas H. ^{[1
,2
,5
]}

机构：

[1] Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Parkville, Vic 3052, Australia

[2] Melbourne Ctr Nanofabricat, Victorian Node Australian Natl Fabricat Facil, Clayton, Vic 3168, Australia

[3] Guangdong Technion Israel Inst Technol, Fac Biotechnol & Food Engn, Shantou 515063, Peoples R China

[4] Guangdong Technion Israel Inst Technol, Guangdong Prov Key Lab Mat & Technol Energy Conver, Shantou 515063, Peoples R China

[5] Monash Univ, Mat Sci & Engn, Clayton, Vic 3168, Australia

来源：

MOLECULAR PHARMACEUTICS | 2025年 / 22卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

microneedles; microfabrication; drug delivery; biosensors; theranostics; SELF-ASSEMBLED MONOLAYERS; POLYMERIC MICRONEEDLES; TRANSDERMAL DELIVERY; DRAWING LITHOGRAPHY; ARRAY PATCH; IN-VIVO; FABRICATION; SKIN; NANOPARTICLES; PENETRATION;

D O I：

10.1021/acs.molpharmaceut.4c01266

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain and customizable designs, making them suitable for personalized medicine. Understanding the key design parameters and the challenges during contact with biofluids is crucial to optimizing their use across applications. This review summarizes the current fabrication techniques and design considerations tailored to meet the distinct requirements for drug delivery and biosensing applications. We further underscore the current state of theranostic MNs that integrate drug delivery and biosensing and propose future directions for advancing MNs toward clinical use.

引用

页码：678 / 707

页数：30

共 50 条

[41] Design, fabrication and characterization of in-plane titanium microneedles for transdermal drug delivery
Li, Wen
Zhang, Yiming
Chen, Jing
MEMS/NEMS NANO TECHNOLOGY, 2011, 483 : 532 - 536
[42] Design and characterization of hollow microneedles for localized intrascleral drug delivery of ocular formulations
Gade, Shilpkala
Vora, Lalitkumar K.
Thakur, Raghu Raj Singh
METHODS, 2025, 234 : 196 - 210
[43] Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications
Wang, Rui
Jiang, Guohua
Aharodnikau, Uladzislau E.
Yunusov, Khaydar
Sun, Yanfang
Liu, Tianqi
Solomevich, Sergey O.
MACROMOLECULAR RAPID COMMUNICATIONS, 2022, 43 (08)
[44] Analytical approach for optimization design of MEMS based microneedles in drug delivery system
N. Raja Rajeswari
P. Malliga
Journal of Mechanical Science and Technology, 2015, 29 : 3405 - 3415
[45] Microneedles for non-transdermal drug delivery: design strategies and current applications
Xu, Jinhong
Liao, Xiangyi
Chen, Danli
Jia, Xiuzhuo
Niu, Xufeng
BIO-DESIGN AND MANUFACTURING, 2025, 8 (02) : 243 - 274
[46] Solid silicon microneedles for drug delivery applications
Narayanan, S. Pradeep
Raghavan, S.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY, 2017, 93 (1-4): : 407 - 422
[47] Microneedles array for fluid extraction and drug delivery
Liu, R
Wang, XH
Zhou, ZY
Williams, JD
MHS2003: PROCEEDINGS OF 2003 INTERNATIONAL SYMPOSIUM ON MICROMECHATRONICS AND HUMAN SCIENCE, 2003, : 239 - 244
[48] Microneedles for drug and vaccine delivery and patient monitoring
Donnelly, Ryan
Douroumis, Dennis
DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2015, 5 (04) : 311 - 312
[49] Can Microneedles Revolutionize Ocular Drug Delivery?
Sahinovic, Merima
Tucak-Smajic, Amina
Muhamedagic, Kenan
Hindija, Lamija
Rahic, Ognjenka
Hadziabdic, Jasmina
Vranic, Edina
Cekic, Ahmet
MEDICON 2023 AND CMBEBIH 2023, VOL 1, 2024, 93 : 425 - 433
[50] Panorama of dissolving microneedles for transdermal drug delivery
Dalvi, Mayuri
Kharat, Pratik
Thakor, Pradip
Bhavana, Valamla
Singh, Shashi Bala
Mehra, Neelesh Kumar
LIFE SCIENCES, 2021, 284

← 1 2 3 4 5 →