The application of nanodiscs in membrane protein drug discovery & development and drug delivery

被引：0

作者：

Dong, Yingkui ^{[1
,2
]}

Tang, Huan ^{[3
]}

Dai, Han ^{[1
]}

Zhao, Hongxin ^{[1
,3
]}

Wang, Junfeng ^{[1
,2
,4
]}

机构：

[1] Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei, Anhui, Peoples R China

[2] Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Anhui, Peoples R China

[3] Hefei China Sci Longwood Biol Technol Co Ltd, Hefei, Anhui, Peoples R China

[4] Univ Sci & Technol China, Hefei, Anhui, Peoples R China

来源：

FRONTIERS IN CHEMISTRY | 2024年 / 12卷

关键词：

nanodisc (ND); membrane protein; drug discovery & development; drug delievery; membrane scaffold protein (MSP); PHOSPHOLIPID-BILAYER NANODISCS; NANOPARTICLES; DETERGENT; RECEPTOR; SCAFFOLD; NITRATE;

D O I：

10.3389/fchem.2024.1444801

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The phospholipid bilayer nanodiscs (LNDs), as a rapidly-developing tool in recent years, provide a natural bio-memebrane environment to maintain the native conformation and functions of membrane proteins as well as a versatile delivery vehicle for a variety of hydrophobic and hydrophilic drugs. We have seen unprecedented advantages of phospholipid bilayer nanodiscs in membrane protein structure characterization, biochemical and physiological studies of membrane proteins, membrane environment studies, drug discovery & development, and drug delivery. Many previous reviews have been mainly focused on the advantages of nanodiscs in membrane protein researches, but few have touched upon the importance and potential application of nanodiscs in pharmaceutical industries. This review will provide general description of the structural characteristics, advantages, classification, and applications of phospholipid nanodiscs, with particular focus on nanodisc-enabled membrane protein drug discovery & development as well as drug delivery.

引用

页数：9

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