Anticancer Activities of Natural and Synthetic Steroids: A Review

被引:0
|
作者
Lara, Daniel F. Mendoza [1 ]
Hernandez-Caballero, M. Elena [2 ]
Teran, Joel L. [3 ]
Ramirez, Jesus Sandoval [4 ]
Carrasco-Carballo, Alan [1 ,5 ]
机构
[1] BUAP, Lab Elucidac & Sintesis Quim Organ, ICUAP, Mexico City 03940, Mexico
[2] BUAP, Fac Med, Mexico City 03940, Mexico
[3] BUAP, ICUAP, Ctr Quim, Mexico City 03940, Mexico
[4] BUAP, Lab Sintesis & Modificac Prod Nat, FCQ, Mexico City 03940, Mexico
[5] BUAP, CONAHCYT, LESQO, ICUAP, Mexico City 03940, Mexico
来源
ACS OMEGA | 2025年 / 10卷 / 08期
关键词
D O I
10.1021/acsomega.4c08577
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Steroids have demonstrated a wide field of research on the subject of anticancer compounds, particularly antiproliferative with cell lines, with special emphasis on the historical link between steroids and cancer and the use of in silico technologies to understand the impact of natural and synthetic steroids on cancer cells focused on finding common denominators of the type of structural changes that give antiproliferative and/or cytotoxic properties, both in control and cancer cell lines. Through this review and classification by origin and/or synthesis, it is found that steroidal saponins are highly cytotoxic, although with low selectivity against control cells, while on the part of the aglycone the presence of heteroatoms such as nitrogen and oxygen increases the antiproliferative activity, mainly via cell cycle arrest and the induction of apoptosis, mechanisms that have been partially proven, using semisynthetic derivatives, as well as bioconjugates between saponins and nitrogenous steroids with now a high cytotoxicity and selectivity against control cell lines. This gives rise to the idea that steroids as a study model for the design of anticancer agents are an excellent template with a wide field of study.
引用
收藏
页码:7493 / 7509
页数:17
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