Mitigating Paxlovid™-induced drug-drug interaction toxicity: an in silico insight

被引：0
|
作者：
Ta, Giang H. [1 ]
Leong, Max K. [1 ]
机构：
[1] Natl Dong Hwa Univ, Dept Chem, Hualien, Taiwan
来源：
FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷
关键词：
<italic>in silico</italic>; skin permeability; Paxlovid; nirmatrelvir; COVID-19; PENETRATION; PERMEATION; SKIN;
D O I：
10.3389/fphar.2024.1496630
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The clinical drug-drug interaction side-effects of Ritonavir, an ingredient in Paxlovid (TM), have been documented, highlighting the need to explore alternative administration methods for Nirmatrelvir, another drug in the Paxlovid (TM) combination. In this study, the skin permeability potential of Nirmatrelvir was assessed using various in silico models. The prediction results suggest that Nirmatrelvir could be administrated via the transdermal route, offering a promising avenue to enhance the efficacy of anti-COVID-19 agents.
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页数：3
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