Autoreactive CD8 T cells differ in exhaustion and response to therapy in type 1 diabetes

被引:0
|
作者
Centore, Joshua [1 ]
Wiedeman, Alice [1 ]
Lundy, Steven [1 ]
Serti, Elisavet [2 ]
Long, S. Alice [1 ]
机构
[1] Benaroya Res Inst, Seattle, WA USA
[2] Immune Tolerance Network, Bethesda, MD USA
来源
JOURNAL OF IMMUNOLOGY | 2024年 / 212卷 / 01期
基金
美国国家卫生研究院;
关键词
D O I
10.4049/jimmunol.212.supp.0996.5057
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Detection and Characterization of CD8+ Autoreactive Memory Stem T Cells in Patients With Type 1 Diabetes
    Vignali, Debora
    Cantarelli, Elisa
    Bordignon, Carlotta
    Canu, Adriana
    Citro, Antonio
    Annoni, Andrea
    Piemonti, Lorenzo
    Monti, Paolo
    DIABETES, 2018, 67 (05) : 936 - 945
  • [22] CD4 and CD8 T cells differ in their proliferative responses
    Alice Lorenzi
    Arthritis Research & Therapy, 4 (1)
  • [23] Islet-autoreactive CD4+T cells are linked with response to alefacept in type 1 diabetes
    Balmas, Elisa
    Chen, Janice
    Hu, Alex K.
    DeBerg, Hannah A.
    Rosasco, Mario G.
    Gersuk, Vivian H.
    Serti, Elisavet
    Speake, Cate
    Greenbaum, Carla J.
    Nepom, Gerald T.
    Linsley, Peter S.
    Cerosaletti, Karen
    JCI INSIGHT, 2023, 8 (21)
  • [24] Generation of exhaustion resistant memory CD8 T-cells by simultaneous downmodulation of mTORC1 and PD-1 in activated CD8 T-cells
    Berezhnoy, Alexey
    Levey, Agata
    Rajagopalan, Anugraha
    Puplampu-Dove, Yvonne
    Gilboa, Eli
    CANCER RESEARCH, 2015, 75
  • [25] Characterization of the response T CD8 vis-a-vis to the proinsulin in the diabetes of the type 1 human
    Toma, A
    Haddouk, S
    Carel, JC
    Briand, JP
    Muller, S
    Choppin, J
    Boitard, C
    DIABETES & METABOLISM, 2006, 32 : S15 - S15
  • [26] Autoreactive T cells in human type 1 diabetes
    Tree, TIM
    Peakman, M
    ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2004, 33 (01) : 113 - +
  • [27] Harnessing CD8+ Regulatory T Cells: Therapy for Type 1 Diabetes?
    Zaccone, Paola
    Cooke, Anne
    IMMUNITY, 2010, 32 (04) : 504 - 506
  • [28] Reevaluating the CD8 T-Cell Response to Herpes Simplex Virus Type 1: Involvement of CD8 T Cells Reactive to Subdominant Epitopes
    Sheridan, Brian S.
    Cherpes, Thomas L.
    Urban, Julie
    Kalinski, Pawel
    Hendricks, Robert L.
    JOURNAL OF VIROLOGY, 2009, 83 (05) : 2237 - 2245
  • [29] Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
    Coppieters, Ken T.
    Dotta, Francesco
    Amirian, Natalie
    Campbell, Peter D.
    Kay, Thomas W. H.
    Atkinson, Mark A.
    Roep, Bart O.
    von Herrath, Matthias G.
    JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (01): : 51 - 60
  • [30] The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies
    Faustman, Denise L.
    Davis, Miriam
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2009, 87 (12): : 1173 - 1178