Autoreactive CD8 T cells differ in exhaustion and response to therapy in type 1 diabetes

被引:0
|
作者
Centore, Joshua [1 ]
Wiedeman, Alice [1 ]
Lundy, Steven [1 ]
Serti, Elisavet [2 ]
Long, S. Alice [1 ]
机构
[1] Benaroya Res Inst, Seattle, WA USA
[2] Immune Tolerance Network, Bethesda, MD USA
来源
JOURNAL OF IMMUNOLOGY | 2024年 / 212卷 / 01期
基金
美国国家卫生研究院;
关键词
D O I
10.4049/jimmunol.212.supp.0996.5057
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes
    Pinkse, GGM
    Tysma, OHM
    Bergen, CAM
    Kester, MGD
    Ossendorp, F
    van Veelen, PA
    Keymeulen, B
    Pipeleers, D
    Drijfhout, JW
    Roep, BO
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (51) : 18425 - 18430
  • [2] Differential therapeutic modulation of exhaustion among autoreactive and global CD8 T cells in type 1 diabetes (T1D)
    Wiedeman, Alice E.
    Vega, Carolina Acosta
    Serti, Elisavet
    Nepom, Jerry
    Long, Alice
    JOURNAL OF IMMUNOLOGY, 2022, 208 (01):
  • [3] Islet autoreactive CD8 T-cells in type 1 diabetes - Licensed to kill?
    Roep, Bart O.
    DIABETES, 2008, 57 (05) : 1156 - 1157
  • [4] Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes
    Long, S. Alice
    Thorpe, Jerill
    DeBerg, Hannah A.
    Gersuk, Vivian
    Eddy, James A.
    Harris, Kristina M.
    Ehlers, Mario
    Herold, Kevan C.
    Nepom, Gerald T.
    Linsley, Peter S.
    SCIENCE IMMUNOLOGY, 2016, 1 (05)
  • [6] New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes
    Bender, Christine
    Rajendran, Sakthi
    von Herrath, Matthias G.
    FRONTIERS IN ENDOCRINOLOGY, 2021, 11
  • [7] IFNγ Inhibits Type 1 Diabetes by Blunting Autoreactive CD8 T Cell Responses
    Driver, John P.
    Lamont, Deanna J.
    Mcphee, Caroline
    Chapman, Harry
    Serreze, Dave V.
    DIABETES, 2014, 63 : A429 - A429
  • [8] Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
    Wiedeman, Alice E.
    Muir, Virginia S.
    Rosasco, Mario G.
    DeBerg, Hannah A.
    Presnell, Scott
    Haas, Bertrand
    Dufort, Matthew J.
    Speake, Cate
    Greenbaum, Carla J.
    Serti, Elisavet
    Nepom, Gerald T.
    Blahnik, Gabriele
    Kus, Anna M.
    James, Eddie A.
    Linsley, Peter S.
    Long, S. Alice
    JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (01): : 480 - 490
  • [9] The role of autoreactive CD8+T cells in the development of type 1 diabetes
    Goransson, M.
    Samassa, F.
    Sejero Holm, J.
    Carre, A.
    You, S.
    Lernmark, A.
    Torn, C.
    Ternette, N.
    Mallone, R.
    Reker Hadrup, S.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2021, 94 (06)
  • [10] Apportioning Blame: Autoreactive CD4+ and CD8+ T Cells in Type 1 Diabetes
    Rubén Varela-Calvino
    Cristina Calviño-Sampedro
    Iria Gómez-Touriño
    Oscar J. Cordero
    Archivum Immunologiae et Therapiae Experimentalis, 2017, 65 : 275 - 284