The role of short-chain fatty acid metabolism in the pathogenesis, diagnosis and treatment of cancer

被引：0
|
作者：
Hou, Maolin [1 ]
Yu, Qing-Qing [2 ]
Yang, Le [3 ]
Zhao, Haibo [4 ]
Jiang, Pei [2 ]
Qin, Lei [3 ]
Zhang, Qiujie [4 ]
机构：
[1] Siziwangqi Peoples Hosp, Dept Internal Med, Wulancabu, Peoples R China
[2] Jining 1 Peoples Hosp, Translat Pharmaceut Lab, Jining, Peoples R China
[3] Jining 1 Peoples Hosp, Dept Gastrointestinal Surg, Jining, Peoples R China
[4] Jining 1 Peoples Hosp, Dept Oncol, Jining, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词：
short-chain fatty acid; metabolism; cancer; pathogenesis; diagnosis; treatment; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN GASTRIC-CANCER; CELL-CYCLE ARREST; GUT MICROBIOTA; BUTYRATE; EXPRESSION; APOPTOSIS; RECEPTOR; PROLIFERATION; METHYLATION;
D O I：
10.3389/fonc.2024.1451045
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Short-chain fatty acids (SCFAs), which are saturated fatty acids consisting of six or fewer carbon atoms, have been found to be closely associated with the biological behavior of malignant tumors. This manuscript provides a comprehensive review on the role of SCFAs in regulating cell cycle, apoptosis, tumor angiogenesis, epithelial-mesenchymal transition, protein regulatory pathways, and histone regulation in promoting the development of malignant tumors. Furthermore, we discuss the potential therapeutic strategies targeting SCFAs for treating malignant tumors. This review offers a theoretical foundation for investigating the mechanisms by which SCFAs impact malignant tumors and provides insights into developing novel treatment targets.
引用
收藏
页数：7
相关论文
共 50 条
  • [41] The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications
    Gomes, Sara Daniela
    Oliveira, Claudia Suellen
    Azevedo-Silva, Joao
    Casanova, Marta R.
    Barreto, Judite
    Pereira, Helena
    Chaves, Susana R.
    Rodrigues, Ligia R.
    Casal, Margarida
    Corte-Real, Manuela
    Baltazar, Fatima
    Preto, Ana
    CURRENT MEDICINAL CHEMISTRY, 2020, 27 (24) : 4087 - 4108
  • [42] Dynamic balancing of intestinal short-chain fatty acids: The crucial role of bacterial metabolism
    Xu, Youqiang
    Zhu, Yang
    Li, Xiuting
    Sun, Baoguo
    TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2020, 100 (100) : 118 - 130
  • [43] Impact of Short-Chain Fatty Acids on Glucose, Fatty Acid and Leucine Metabolism in Primary Human Myotubes
    Tingstad, Ragna Husby
    Witczak, Oliwia
    Beajani, Siver
    Seo, Seung Hee
    Lovsletten, Nils Gunnar
    Skagen, Christine
    Myhrstad, Mari Charlotte Wik
    Telle-Hansen, Vibeke Helen
    Eide, Lars
    Rustan, Arild Christian
    Aas, Vigdis
    ENDOCRINOLOGY DIABETES & METABOLISM, 2025, 8 (02)
  • [44] The short-chain fatty acid butyrate is a substrate of breast cancer resistance protein
    Goncalves, Pedro
    Gregorio, Ines
    Martel, Fatima
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2011, 301 (05): : C984 - C994
  • [45] Short-chain fatty acid-hexosamine cancer prodrugs: the sugar matters!
    Sampathkumar, Srinivasa-Gopalan
    Campbell, Christopher T.
    Weier, Christopher
    Yarema, Kevin J.
    DRUGS OF THE FUTURE, 2006, 31 (12) : 1099 - 1116
  • [46] Gut microbiota and short-chain fatty acid alterations in cachectic cancer patients
    Ubachs, Jorne
    Ziemons, Janine
    Soons, Zita
    Aarnoutse, Romy
    Dijk, David P. J.
    Penders, John
    Helvoort, Ardy
    Smidt, Marjolein L.
    Kruitwagen, Roy F. P. M.
    Baade-Corpelijn, Lieke
    Damink, Steven W. M. Olde
    Rensen, Sander S.
    JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2021, 12 (06) : 2007 - 2021
  • [47] Short-chain fatty acid sensing in rat duodenum
    Akiba, Yasutada
    Inoue, Takuya
    Kaji, Izumi
    Higashiyama, Masaaki
    Narimatsu, Kazuyuki
    Iwamoto, Ken-ichi
    Watanabe, Masahiko
    Guth, Paul H.
    Engel, Eli
    Kuwahara, Atsukazu
    Kaunitz, Jonathan D.
    JOURNAL OF PHYSIOLOGY-LONDON, 2015, 593 (03): : 585 - 599
  • [48] Short-Chain Fatty Acid Receptors and Cardiovascular Function
    Lymperopoulos, Anastasios
    Suster, Malka S.
    Borges, Jordana, I
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (06)
  • [49] ROLE OF SHORT-CHAIN FATTY-ACIDS IN THE PREVENTION OF COLORECTAL-CANCER
    SCHEPPACH, W
    BARTRAM, HP
    RICHTER, F
    EUROPEAN JOURNAL OF CANCER, 1995, 31A (7-8) : 1077 - 1080
  • [50] Short-chain fatty acid signaling in retinopathy of prematurity
    Bui, Tommy
    Oxenrider, Allston
    Amaoo, Ronny
    Martin, Pamela M.
    Thounaojam, Menaka
    Jadeja, Ravirajsinh
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (08)
12345