BET inhibition modulates the functional phenotype and plasticity of tumor-associated macrophages and improves survival: Next frontier in overcoming immunotherapy resistance in ovarian cancer

被引:0
|
作者
Mahira, Shaheen [1 ]
Panesso-Gomez, Santiago [1 ]
Jones, Philip [1 ]
Jawadi, Mohamad [1 ]
Olawaiye, Alexander [1 ]
Mahdi, Haider [1 ]
机构
[1] Univ Pittsburgh, Med Ctr, Magee Womens Womens Hosp, Pittsburgh, PA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1294
引用
收藏
页码:S239 / S239
页数:1
相关论文
共 36 条
  • [21] PVRL2 upregulation by tumor-associated macrophages confers a regulatory phenotype and is associated with poor prognosis in high-grade serous ovarian cancer
    Murakami, Kosuke
    Ando, Hirofumi
    Doucet, Michele
    Ding, Dacheng
    Huang, William
    Ganguly, Sudipto
    CANCER RESEARCH, 2024, 84 (06)
  • [22] Nitric Ocide Genenrated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition
    Perrotta, Cristiana
    Cervia, Davide
    Di Renzo, Ilaria
    Moscheni, Claudia
    Bassi, Maria Teresa
    Campana, Lara
    Martelli, Cristina
    Catalani, Elisabetta
    Giovarelli, Matteo
    Zecchini, Silvia
    Coazzoli, Marco
    Capobianco, Annalisa
    Ottobrini, Luisa
    Lucignani, Giovanni
    Rosa, Patrizia
    Rovere-Querini, Patrizia
    De Palma, Clara
    Clementi, Emilio
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [23] DEPLETION OF INTRATUMORAL TUMOR-ASSOCIATED MACROPHAGES AND MICROGLIA (TAM/M) IMPROVES CHECKPOINT-INHIBITION THERAPY FOR BRAIN METASTASIS FROM LUNG CANCER
    Karschnia, Philipp
    Xu, Tao
    Fitzinger, Esther
    Saliger, Julia C.
    Blobner, Jens
    Teske, Nico
    von Muecke-Heim, Iven-Alex
    Langer, Sigrid
    Konhauser, Marcel
    Ishikawa-Ankerhold, Hellen
    Thon, Niklas
    Tonn, Jorg-Christian
    von Baumgarten, Louisa
    NEURO-ONCOLOGY, 2021, 23 : 198 - 198
  • [24] STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
    Qiwei Wang
    Johann S. Bergholz
    Liya Ding
    Ziying Lin
    Sheheryar K. Kabraji
    Melissa E. Hughes
    Xiadi He
    Shaozhen Xie
    Tao Jiang
    Weihua Wang
    Jason J. Zoeller
    Hye-Jung Kim
    Thomas M. Roberts
    Panagiotis A. Konstantinopoulos
    Ursula A. Matulonis
    Deborah A. Dillon
    Eric P. Winer
    Nancy U. Lin
    Jean J. Zhao
    Nature Communications, 13
  • [25] STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
    Wang, Qiwei
    Bergholz, Johann S.
    Ding, Liya
    Lin, Ziying
    Kabraji, Sheheryar K.
    Hughes, Melissa E.
    He, Xiadi
    Xie, Shaozhen
    Jiang, Tao
    Wang, Weihua
    Zoeller, Jason J.
    Kim, Hye-Jung
    Roberts, Thomas M.
    Konstantinopoulos, Panagiotis A.
    Matulonis, Ursula A.
    Dillon, Deborah A.
    Winer, Eric P.
    Lin, Nancy U.
    Zhao, Jean J.
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [26] CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype
    Li, Han
    Luo, Fan
    Jiang, Xingyu
    Zhang, Weijing
    Xiang, Tong
    Pan, Qiuzhong
    Cai, Liming
    Zhao, Jingjing
    Weng, Desheng
    Li, Yue
    Dai, Yuhu
    Sun, Fengze
    Yang, Chaopin
    Huang, Yue
    Yang, Jieying
    Tang, Yan
    Han, Yulong
    He, Mian
    Zhang, Yanna
    Song, Libing
    Xia, Jian-Chuan
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (03)
  • [27] Tumor-Associated Microglia/Macrophages as a Predictor for Survival in Glioblastoma and Temozolomide-Induced Changes in CXCR2 Signaling with New Resistance Overcoming Strategy by Combination Therapy
    Urbantat, Ruth M.
    Jelgersma, Claudius
    Brandenburg, Susan
    Nieminen-Kelha, Melina
    Kremenetskaia, Irina
    Zollfrank, Julia
    Mueller, Susanne
    Rubarth, Kerstin
    Koch, Arend
    Vajkoczy, Peter
    Acker, Gueliz
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (20)
  • [28] Intratumoral T cells, tumor-associated macrophages, and regulatory T cells: Association with p53 mutations, circulating tumor DNA and survival in women with ovarian cancer
    Shah, Chirag A.
    Allison, Kimberly H.
    Garcia, Rochelle L.
    Gray, Heidi J.
    Goff, Barbara A.
    Swisher, Elizabeth M.
    GYNECOLOGIC ONCOLOGY, 2008, 109 (02) : 215 - 219
  • [29] Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B
    Xun, Jing
    Du, Lingfang
    Gao, Ruifang
    Shen, Long
    Wang, Dekun
    Kang, Lichun
    Chen, Chuan'ai
    Zhang, Zhujun
    Zhang, Yuying
    Yue, Shijing
    Feng, Shuxin
    Xiang, Rong
    Mi, Xue
    Tan, Xiaoyue
    THERANOSTICS, 2021, 11 (14): : 6847 - 6859
  • [30] Polarisation of Tumor-Associated Macrophages toward M2 Phenotype Correlates with Poor Response to Chemoradiation and Reduced Survival in Patients with Locally Advanced Cervical Cancer
    Petrillo, Marco
    Zannoni, Gian Franco
    Martinelli, Enrica
    Anchora, Luigi Pedone
    Ferrandina, Gabriella
    Tropeano, Giovanna
    Fagotti, Anna
    Scambia, Giovanni
    PLOS ONE, 2015, 10 (09):