Fermented Soymilk with Probiotic Lactobacilli and Bifidobacterium Strains Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Rats

被引:2
|
作者
Al Zahrani, Ashwag Jaman [1 ]
Shori, Amal Bakr [2 ]
Al-Judaibi, Effat [1 ]
机构
[1] Univ Jeddah, Fac Sci, Dept Biol Sci, Jeddah 21959, Saudi Arabia
[2] King Abdulaziz Univ, Fac Sci, Dept Biol Sci, Jeddah 21589, Saudi Arabia
关键词
inflammation; colitis; fermented soymilk; dextran sulfate sodium; Lactobacilli; Bifidobacterium; INFLAMMATORY-BOWEL-DISEASE; LACTIC-ACID BACTERIA; GUT MICROBIOTA; ULCERATIVE-COLITIS; INTESTINAL INFLAMMATION; SOY MILK; HEALTH; DIET; IBD; STARTER;
D O I
10.3390/nu16203478
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Current treatments for inflammatory bowel disease (IBD) are relatively futile and the extended use of drugs may reduce effectiveness. Several probiotic strains have shown promise in relieving/treating IBD symptoms. Objectives: The current study investigated the impact of fermented soymilk with a mixture of probiotic starter cultures containing Lactobacillus rhamnosus, L. casei, L. plantarum, L. acidophilus, Bifidobacterium longum, and B. animalis subsp. lactis in rats with dextran sulfate sodium (DSS)-induced colitis compared to control. Methods: Rats were randomly assigned to five groups (5 rats/group; n = 25): G1: negative normal control; G2: positive control (DSS); G3: DSS with sulfasalazine (DSS-Z); G4: DSS with soymilk (DSS-SM), and G5: DSS with fermented soymilk (DSS-FSM). Parameters monitored included the following: the disease activity index (DAI), macroscopic and histological assessments of colitis, and a fecal microbial analysis performed to assess the severity of inflammation and ulceration. Results: The DSS-FSM rats group exhibited lower DAI scores (p < 0.05) than other treated groups during the induction period. A macroscopical examination revealed no ulceration or swelling in the intestinal mucosa of rats in the DSS-FSM-treated group, resembling the findings in the negative control group. In the positive control (DSS group), the colon tissue showed increased inflammation (p < 0.05), whereas those in the DSS-SM- and DSS-FSM-treated rats groups did not show significant macroscopic scores of colitis. The positive DSS control and DSS-Z groups had crypt erosion and ulceration areas, severe crypt damage, and epithelial surface erosion, which were absent in the negative control and DSS-FSM groups. The counts of Lactobacillus spp. and Bifidobacterium spp. remained stable in both G1 and G5 over 4 weeks. The consumption of fermented soymilk with a mixture of probiotics could minimize the severity of DSS-induced colitis in rats. Conclusion, it was found that fermented soymilk containing Lactobacilli and Bifidobacterium might be an effective vehicle for reducing the severity of DSS-induced colitis in rats.
引用
收藏
页数:18
相关论文
共 50 条
  • [42] Immunoprotective Effect of Probiotic Dahi Containing Lactobacillus acidophilus and Bifidobacterium bifidum on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice
    Sagar R. Jadhav
    Umesh Kr. Shandilya
    Vinod K. Kansal
    Probiotics and Antimicrobial Proteins, 2012, 4 : 21 - 26
  • [43] Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice
    Guo, Bao-Jian
    Liu, Zhuyun
    Ding, Mo-Yu
    Li, Feng
    Jing, Mei
    Xu, Li-Peng
    Wang, Yu-Qiang
    Zhang, Zai-Jun
    Wang, Yitao
    Wang, Decai
    Zhou, Guo-Chun
    Wang, Ying
    BIOCHEMICAL PHARMACOLOGY, 2019, 163 : 416 - 424
  • [44] Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo
    Jeon, Yong-Deok
    Kang, Sa-Haeng
    Bang, Keuk-Soo
    Chang, Young-Nam
    Lee, Jong-Hyun
    Jin, Jong-Sik
    MOLECULES, 2016, 21 (04)
  • [45] Novel Phocaeicola Strain Ameliorates Dextran Sulfate Sodium-induced Colitis in Mice
    Sun, Zhen
    Jiang, Xinye
    Wang, Botao
    Tian, Fengwei
    Zhang, Heng
    Yu, Leilei
    CURRENT MICROBIOLOGY, 2022, 79 (12)
  • [46] Nitrate ameliorates dextran sodium sulfate -induced colitis by regulating the homeostasis of the intestinal microbiota
    Hu, Liang
    Jin, Luyuan
    Xia, Dengsheng
    Zhang, Qian
    Ma, Linsha
    Zheng, Hui
    Xu, Tiansong
    Chang, Shimin
    Li, Xiangchun
    Xun, Zhe
    Xu, Yipu
    Zhang, Chunmei
    Chen, Feng
    Wang, Songlin
    FREE RADICAL BIOLOGY AND MEDICINE, 2020, 152 : 609 - 621
  • [47] Novel Phocaeicola Strain Ameliorates Dextran Sulfate Sodium-induced Colitis in Mice
    Zhen Sun
    Xinye Jiang
    Botao Wang
    Fengwei Tian
    Heng Zhang
    Leilei Yu
    Current Microbiology, 2022, 79
  • [48] Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice
    Liu, Bo
    Lin, Qinlu
    Yang, Tao
    Zeng, Linna
    Shi, Limin
    Chen, Yaya
    Luo, Feijun
    FOOD & FUNCTION, 2015, 6 (11) : 3454 - 3463
  • [49] Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis
    Wu, Xiaxia
    Guo, Yanling
    Min, Xiangjing
    Pei, Lixia
    Chen, Xiuping
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2018, 46 (06): : 1263 - 1279
  • [50] Pingwei San ameliorates dextran sulfate sodium-induced chronic colitis in mice
    Zhang, Zecai
    Shen, Peng
    Xie, Wenbing
    Cao, Hongyang
    Liu, Jiuxi
    Cao, Yongguo
    Zhang, Naisheng
    JOURNAL OF ETHNOPHARMACOLOGY, 2019, 236 : 91 - 99