Tacrolimus-induced thrombotic microangiopathy (TMA) after heart and lung transplantation successfully treated with eculizumab

被引：0
|
作者：
Kattih, Zein [1 ]
Iacono, Aldo [2 ]
Saikus, Christina [2 ]
Esposito, Michael [3 ]
Kon, Zachary [2 ]
Korotun, Maksim [2 ]
机构：
[1] Lenox Hill Hosp, Pulm & Crit Care, 100 E 77th St,4East, New York, NY 10075 USA
[2] Northwell Hlth Syst, Pulm Crit Care & Cardiothorac Surg, 300 Community Dr, Manhasset, NY 11030 USA
[3] Northwell Hlth Syst, Pathol, 300 Community Dr, Manhasset, NY 11030 USA
来源：
TRANSPLANT IMMUNOLOGY | 2025年 / 88卷
关键词：
Systemic lupus erythematosus (SLE); Thrombotic microangiopathy (TMA); Acute kidney injury (AKI); Heart and lung transplantation;
D O I：
10.1016/j.trim.2024.102169
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Introduction: Tacrolimus-induced thrombotic microangiopathy (TMA) causing acute kidney injury (AKI) without systemic features is a rare entity, particularly after non-renal solid organ transplantation. Case report: We describe the case of a patient with AKI after combined heart and lung transplantation. Renal biopsy revealed acute thrombotic microangiopathy which ultimately prompted initiation of eculizumab, a monoclonal antibody targeted against complement C5, with subsequent recovery in renal function. Results/conclusion: This case highlights renal isolated drug-induced TMA as a rarely reported cause of AKI post heart-lung transplantation. We emphasize the importance of performing a renal biopsy in guiding management strategies.
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页数：3
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