Polycaprolactone in Bone Tissue Engineering: A Comprehensive Review of Innovations in Scaffold Fabrication and Surface Modifications

被引：2

作者：

Liang, Hsin-Yu ^{[1
]}

Lee, Wei-Keung ^{[2
]}

Hsu, Jui-Tsen ^{[1
]}

Shih, Jie-Yu ^{[1
]}

Ma, Tien-Li ^{[3
]}

Vo, Thi Thuy Tien ^{[4
]}

Lee, Chiang-Wen ^{[5
,6
,7
,8
]}

Cheng, Ming-Te ^{[9
,10
,11
,12
]}

Lee, I-Ta ^{[1
]}

机构：

[1] Taipei Med Univ, Coll Oral Med, Sch Dent, Taipei 11031, Taiwan

[2] Taoyuan Gen Hosp, Dept Phys Med & Rehabil, Minist Hlth & Welf, Taoyuan 33004, Taiwan

[3] Taipei Med Univ, Coll Oral Med, Sch Dent Technol, Taipei 11031, Taiwan

[4] Nguyen Tat Thanh Univ, Fac Dent, Ho Chi Minh 70000, Vietnam

[5] Chang Gung Univ Sci & Technol, Dept Nursing, Div Basic Med Sci, Chiayi 61363, Taiwan

[6] Chang Gung Univ Sci & Technol, Chron Dis & Hlth Promot Res Ctr, Chiayi 61363, Taiwan

[7] Chang Gung Univ Sci & Technol, Dept Resp Care, Chiayi 61363, Taiwan

[8] Chang Gung Mem Hosp, Dept Orthopaed Surg, Chiayi 61363, Taiwan

[9] Taoyuan Gen Hosp, Dept Orthoped Surg, Minist Hlth & Welf, Taoyuan 33004, Taiwan

[10] Natl Yang Ming Chiao Tung Univ, Coll Med, Taipei 11221, Taiwan

[11] Chung Yuan Christian Univ, Dept Biomed Engn, Taoyuan 32023, Taiwan

[12] Taoyuan Gen Hosp, Dept Orthoped Surg, Sinwu Branch, Minist Hlth & Welf, Taoyuan 32748, Taiwan

来源：

JOURNAL OF FUNCTIONAL BIOMATERIALS | 2024年 / 15卷 / 09期

关键词：

bone tissue engineering; polycaprolactone; 3D printing; scaffold modification; surface coatings; hydroxyapatite; nanomaterials; graphene oxide; BETA-TRICALCIUM PHOSPHATE; COMPOSITE SCAFFOLDS; OPTIMIZATION; CELLS;

D O I：

10.3390/jfb15090243

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Bone tissue engineering has seen significant advancements with innovative scaffold fabrication techniques such as 3D printing. This review focuses on enhancing polycaprolactone (PCL) scaffold properties through structural modifications, including surface treatments, pore architecture adjustments, and the incorporation of biomaterials like hydroxyapatite (HA). These modifications aim to improve scaffold conformation, cellular behavior, and mechanical performance, with particular emphasis on the role of mesenchymal stem cells (MSCs) in bone regeneration. The review also explores the potential of integrating nanomaterials and graphene oxide (GO) to further enhance the mechanical and biological properties of PCL scaffolds. Future directions involve optimizing scaffold structures and compositions for improved bone tissue regeneration outcomes.

引用

页数：18

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