A multi-functional synergistic platform of Cas12a split dsDNA activators

被引：0
|
作者：
Li, Xiaolong [1 ]
Wang, Jiarun [1 ]
Cheng, Xianzhi [1 ]
Xu, Qin [1 ]
She, Lan [2 ]
Wu, Tongbo [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China
[2] Naval Med Univ, Dept Inorgan Chem, 325 Guohe Rd, Shanghai 200433, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2025年
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1039/d5cc01613d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This work comprehensively explores the effects of various positions of Cas12a split activators. Based on this, a multi-functional synergistic platform was constructed. The construction of a structural dynamic network, the sensitive detection of APE1, and a time-controlled photo-activation have been achieved, demonstrating the potential for expanding Cas12a applications.
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页数：4
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