"Naked Nickel"-Catalyzed Heteroaryl-Heteroaryl Suzuki-Miyaura Coupling

被引：0
|
作者：
Saeb, Rakan [1 ]
Roh, Byeongdo [1 ]
Cornella, Josep [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2025年
关键词：
Boron; Cross-coupling; Heterocycles; Nickel; Synthetic methods; VERSATILE METHOD; LIGATION STATE; BORONIC ACIDS; ARYL; PALLADIUM; HALIDES; PRECATALYSTS; COMPLEXES; CHLORIDES; REACTIVITY;
D O I：
10.1002/anie.202424051
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this article, we report that the air-stable "naked nickel", [Ni(4-CF3stb)3], is a competent catalyst in the catalytic Suzuki-Miyaura cross-coupling reaction (SMC) between heteroaryl bromides and heteroaromatic boron-based nucleophiles. The catalytic system is characterized by its ability to avoid decomposition or deactivation in the presence of multiple Lewis basic sites. The protocol permits the formation of C-C bonds between two heteroaryl moieties in the absence of complex exogenous ligands, thus minimizing screening procedures and simplifying reaction setups. This method accommodates combinations of distinct 6-membered heteroaryl bromides and 5- and 6-membered heterocyclic B-based nucleophiles.
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页数：6
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