The progress of Mycobacterium tuberculosis drug targets

被引：1
|
作者：
Zhang, Xin [1 ]
Zhao, Ruixia [1 ]
Qi, Yao [1 ]
Yan, Xiong [1 ]
Qi, Gaoxiu [1 ]
Peng, Qiuju [2 ]
机构：
[1] Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Qingdao Cent Med Grp, Qingdao, Shandong, Peoples R China
[2] Qingdao Chest Hosp, Qingdao, Shandong, Peoples R China
来源：
FRONTIERS IN MEDICINE | 2024年 / 11卷
关键词：
<italic>Mycobacterium tuberculosis</italic>; anti-tuberculosis drug; target; cell wall synthesis correlation; DNA/RNA synthesis correlation; energy metabolism; DEPENDENT REGULATOR IDER; HOST-IMMUNE-RESPONSE; INHIBITORS; POTENT; DESIGN; SQ109; DISCOVERY;
D O I：
10.3389/fmed.2024.1455715
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Tuberculosis (TB) has been troubling humans for hundreds of years, is a highly infectious disease caused by Mycobacterium tuberculosis (Mtb) infection, Mtb can infect almost all organs of the body and is one of the deadly infectious diseases in the world. At present, the first-line treatment regimen has a long treatment cycle and is prone to multiple drug resistance. Anti-tuberculosis drugs and latent tuberculosis infection (LTBI) resistance are increasing year by year, and new targets and new bioactive compounds are urgently needed to treat this disease. This review focuses on the latest reported anti-TB drug targets and related compounds in recent years, reviews the current TB drug regimen and major defects, outlines the key drug targets developed to date in Mtb, and the current situation of newly discovered anti-TB resistant forms of drugs. To provide a reference for the research and development of new anti-TB drugs and bring new treatment strategies for TB patients.
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页数：11
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