Base-mediated denitrative C3-alkylation of quinoxaline derivatives

被引：0
|
作者：
Pansare, Vaibhav Ramachandra [1 ,2 ]
Barsu, Nagaraju [1 ,2 ]
机构：
[1] CSIR Natl Chem Lab, Organ Chem Div, Dr Homi Bhabha Rd, Pune 411008, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 02期
关键词：
MICHAEL ADDITION; NITROALKANES; NITROMETHANE; PYRIDAZINES; ALKYLATION;
D O I：
10.1039/d4ob01571a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a novel base-mediated method for the selective C3-alkylation of quinoxalin-2(1H)-one and N-protected quinoxalin-2(1H)-one using inexpensive, unactivated nitroalkanes. This approach tolerates a wide range of functional groups and supports the synthesis of various bioactive compounds. Gram-scale reactions demonstrate the scalability of the method. The proposed mechanism was validated by control experiments.
引用
收藏
页码：303 / 307
页数：5
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