Base-mediated denitrative C3-alkylation of quinoxaline derivatives

被引：0

作者：

Pansare, Vaibhav Ramachandra ^{[1
,2
]}

Barsu, Nagaraju ^{[1
,2
]}

机构：

[1] CSIR Natl Chem Lab, Organ Chem Div, Dr Homi Bhabha Rd, Pune 411008, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 02期

关键词：

MICHAEL ADDITION; NITROALKANES; NITROMETHANE; PYRIDAZINES; ALKYLATION;

D O I：

10.1039/d4ob01571a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a novel base-mediated method for the selective C3-alkylation of quinoxalin-2(1H)-one and N-protected quinoxalin-2(1H)-one using inexpensive, unactivated nitroalkanes. This approach tolerates a wide range of functional groups and supports the synthesis of various bioactive compounds. Gram-scale reactions demonstrate the scalability of the method. The proposed mechanism was validated by control experiments.

引用

页码：303 / 307

页数：5

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