Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study

被引:0
|
作者
Li, Yixuan [1 ]
Wang, Yahao [2 ]
Xu, Lili [1 ]
Liu, Chuanfeng [3 ]
Cui, Jiufa [4 ]
Huang, Yajing [1 ]
Li, Shufa [1 ]
Wang, Yangang [1 ]
Dong, Bingzi [1 ]
机构
[1] Qingdao Univ, Dept Endocrinol, Affiliated Hosp, Qingdao, Peoples R China
[2] Fudan Univ, Huashan Hosp, Dept Endocrinol, Shanghai, Peoples R China
[3] Qingdao Univ, Dept Hematol, Affiliated Hosp, Qingdao, Peoples R China
[4] Qingdao Univ, Dept Radiol, Affiliated Hosp, Qingdao, Peoples R China
来源
基金
中国国家自然科学基金;
关键词
bone erosion; magnesium; gouty arthritis; gout; biochemical markers of bone turnover; EXTRACELLULAR MAGNESIUM; DIETARY MAGNESIUM; MINERAL DENSITY; OSTEOPOROSIS; DEFICIENCY; DIFFERENTIATION; ASSOCIATION; RISK; OSTEOCLAST; MECHANISMS;
D O I
10.3389/fendo.2024.1375871
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Gouty arthritis is a common inflammatory arthritis. The recurrent gout attacks severely damage the joint's function, lead to bone erosion, and affect bone metabolism. The role of magnesium (Mg) ions in bone homeostasis has been recognized, whereas its specific relationship with gouty bone erosion remains unclear. This study examined the association between serum ionized Mg levels and bone erosion in patients with gout arthritis. Methods: A total of 769 patients with gout arthritis were included in the study. Participants were classified into four groups based on the quartiles of the serum ionized Mg level. Logistic regression analysis assessed the association between serum ionized Mg and bone erosion. Results: Compared to patients without bone erosion, serum ionized Mg levels were lower in gout patients with bone erosion (p<0.001). When dividing serum ionized Mg into quartiles, the prevalence rate of bone erosion in group Q1, representing the patients with the lowest serum ionized Mg levels, was notably higher than in Q2, Q3, and Q4 (60.2% vs. 43.6%, 45.6%, 40.3%, p<0.001). Multiple logistic regression analysis revealed that patients in Q2-Q4 had a lower odds ratio (OR) of bone erosion compared to those in Q1 (ORs were 0.520, 0.533, and 0.411 in Q2-Q4, respectively, p<0.001). Conclusion: The incidence of bone erosion is higher in gout arthritis patients with lower serum ionized Mg levels. High serum ionized Mg levels may be an independent protective factor for bone erosion in gout arthritis. Thus, Mg supplementation may be a promising approach to prevent or slow down the development of bone erosion in gouty arthritis.
引用
收藏
页数:11
相关论文
共 50 条
  • [31] NEUROPATHIC PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS: A CROSS-SECTIONAL STUDY
    Akkar, O.
    Lehraiki, M.
    Azzouzi, H.
    Boutouala, L.
    Ichchou, L.
    ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 : 977 - 977
  • [32] Association Between Serum Magnesium and the Prevalence of Kidney Stones: a Cross-sectional Study
    Wu, Jing
    Yang, Zidan
    Wei, Jie
    Zeng, Chao
    Wang, Yilun
    Yang, Tubao
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2020, 195 (01) : 20 - 26
  • [33] Association Between Serum Magnesium and the Prevalence of Kidney Stones: a Cross-sectional Study
    Jing Wu
    Zidan Yang
    Jie Wei
    Chao Zeng
    Yilun Wang
    Tubao Yang
    Biological Trace Element Research, 2020, 195 : 20 - 26
  • [34] Serum magnesium and proton-pump inhibitors use: a cross-sectional study
    Moreira Faulhaber, Gustavo Adolpho
    Ascoli, Bruna Maria
    Lubini, Adriano
    Mossmann, Marcio
    Rossi, Gabriela
    Geib, Guilherme
    Furlanetto, Tania Weber
    REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2013, 59 (03): : 276 - 279
  • [35] Factors in Achieving Serum Uric Acid Target and the Occurrence of Gouty Arthritis: A Cross-sectional Study Based on Japanese Health Insurance Claim Data
    Koto, Ruriko
    Nakajima, Akihiro
    Horiuchi, Hideki
    Yamanaka, Hisashi
    ARTHRITIS & RHEUMATOLOGY, 2019, 71
  • [36] Higher dietary diversity as a protective factor against depression among older adults in China: a cross-sectional study
    Li, Rong
    Zong, Zhi-Ying
    Gu, Xi-Xi
    Wang, Dan-Ni
    Dong, Chen
    Sun, Chi
    Zhao, Rui
    Gu, Zhi-Feng
    Gao, Jian-Lin
    ANNALS OF PALLIATIVE MEDICINE, 2022, 11 (04) : 1278 - +
  • [37] Digital competence as a protective factor against gaming addiction in children and adolescents: A cross-sectional study in Hong Kong
    Tso, Winnie W. Y.
    Reichert, Frank
    Law, Nancy
    Fu, King Wa
    de la Torre, Jimmy
    Rao, Nirmala
    Leung, Lok Kan
    Wang, Yu-Liang
    Wong, Wilfred H. S.
    Ip, Patrick
    LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2022, 20
  • [38] Digital competence as a protective factor against gaming addiction in children and adolescents: A cross-sectional study in Hong Kong
    Tso, Winnie W. Y.
    Reichert, Frank
    Law, Nancy
    Fu, King Wa
    de la Torre, Jimmy
    Rao, Nirmala
    Leung, Lok Kan
    Wang, Yu-Liang
    Wong, Wilfred H. S.
    Ip, Patrick
    LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2022, 20
  • [39] Ovo-lactovegetarian diet as a possible protective factor against gallbladder polyps in Taiwan: A cross-sectional study
    Liu, Hao-Wen
    Chen, Cheng-Yu
    TZU CHI MEDICAL JOURNAL, 2019, 31 (01): : 29 - 34
  • [40] Protective and risk factors of workplace violence against nurses: A cross-sectional study
    Bagnasco, Annamaria
    Catania, Gianluca
    Pagnucci, Nicola
    Alvaro, Rosaria
    Cicolini, Giancarlo
    Dal Molin, Alberto
    Lancia, Loreto
    Lusignani, Maura
    Mecugni, Daniela
    Motta, Paolo Carlo
    Watson, Roger
    Hayter, Mark
    Timmins, Fiona
    Aleo, Giuseppe
    Napolitano, Francesca
    Signori, Alessio
    Zanini, Milko
    Sasso, Loredana
    Mazzoleni, Beatrice
    JOURNAL OF CLINICAL NURSING, 2024, 33 (12) : 4748 - 4758