A Phase 1, Open-label, Dose-escalating Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ALXN1850 in Adults With Hypophosphatasia

被引:0
|
作者
Dahir, Kathryn [1 ]
Dunn, Derek [2 ]
Hasan, Jawad [2 ]
Shannon, Amy [2 ]
Pan, Wei-Jian [2 ]
机构
[1] Vanderbilt Univ, Med Ctr, Nashville, TN USA
[2] Alexion, AstraZeneca Rare Dis, Boston, MA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
SUN-492
引用
收藏
页码:374 / 374
页数:1
相关论文
共 50 条
  • [31] An Open-Label Phase 2a Study to Evaluate the Safety and Tolerability of Perampanel in Cervical Dystonia
    Fox, Susan H.
    Swan, Matthew
    Jinnah, Hyder A.
    Freitas, Maria E. T.
    Oliveira, Lais M.
    Al-Shorafat, Duha
    Fernandez, Hubert H.
    Kompoliti, Katie
    Comella, Cynthia
    MOVEMENT DISORDERS CLINICAL PRACTICE, 2021, 8 (05): : 743 - 749
  • [32] Optimal dose and safety of intravenous favipiravir in hospitalized patients with SARS-COV-2: A phase I, open-label, dose-escalating, randomized controlled study
    Rowland, Tim
    FitzGerald, Richard
    Else, Laura
    Challenger, Elizabeth
    Dickinson, Laura
    Walker, Lauren
    Hale, Colin
    Lyon, Rebecca
    Dhamani, Karim
    Irwin, Margaret
    Enever, Yvanne
    Tetlow, Michelle
    Osanlou, Orod
    Reynolds, Helen
    Chiong, Justin
    Pertinez, Henry
    Owen, Andrew
    Saunders, Geoff
    Griffiths, Gareth
    Khoo, Saye
    Fletcher, Tom
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2024, 90 : 8 - 9
  • [33] Tolerability and safety of facilitated subcutaneous immunoglobulin 20% in healthy adults: a phase 1 open-label study
    Nagy, Andras
    Khaskhely, Noor
    Duff, Kimberly
    Bauer, Alexander
    Okonneh, Fred
    Rondon, Juan Carlos
    Yel, Leman
    Li, Zhaoyang
    CLINICAL IMMUNOLOGY, 2023, 250 : 36 - 36
  • [34] Phase 1 open-label study evaluating pharmacokinetics, safety, and tolerability of linifanib in Japanese patients with solid tumors
    Tamura, Tomohide
    Yamamoto, Noboru
    Nokihara, Hiroshi
    Yamada, Yasuhide
    Asahina, Hajime
    Shibata, Takashi
    Goto, Yasushi
    Tanioka, Maki
    Tamura, Yosuke
    Seki, Yoshitaka
    Chiu, Yi-Lin
    Gupta, Neeraj
    Carlson, Dawn
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [35] A Phase 1, Open-Label, Dose-Escalation Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Oral Azacitidine in Patients with Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML)
    Garcia-Manero, Guillermo
    Gore, Steven D.
    Skikne, Barry
    Cogle, Christopher R.
    Ning, Yuhong
    MacBeth, Kyle J.
    Laille, Eric
    Ward, M. Renee
    BLOOD, 2009, 114 (22) : 53 - 53
  • [36] PHARMACOKINETICS, SAFETY, AND TOLERABILITY OF OXFENDAZOLE IN HEALTHY ADULTS IN AN OPEN LABEL PHASE 1 MULTIPLE ASCENDING DOSE AND FOOD EFFECT STUDY.
    Bach, T.
    Galbiati, S.
    Kennedy, J.
    Deye, G.
    Nomicos, E.
    Codd, E.
    Garcia, H.
    Horton, J.
    Gilman, R.
    Gonzalez, A.
    Winokur, P.
    An, G.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021, 109 : S17 - S17
  • [37] A phase I, open-label, single-dose study to evaluate the effect of hepatic impairment on the pharmacokinetics and safety of futibatinib
    Gao, Ling
    Yamamiya, Ikuo
    Pinti, Mark
    Rondon, Juan Carlos
    Marbury, Thomas
    Tomlinson, Gareth
    Makris, Lukas
    Hangai, Nanae
    Wacheck, Volker
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2023, 16 (09): : 1713 - 1724
  • [38] Phase 1, open-label, single-dose study to evaluate the effect of hepatic impairment on the pharmacokinetics and safety of futibatinib in adult subjects
    Gao, Ling
    Yamamiya, Ikuo
    Pinti, Mark
    Rondon, Juan Carlos
    Gareth, Thomas Marbury
    Tomlinson, Gareth
    Makris, Lukas
    Hangai, Nanae
    Wacheck, Volker
    CANCER RESEARCH, 2023, 83 (08)
  • [39] Pharmacokinetics, Pharmacodynamics, and Tolerability of Opicapone in Healthy Chinese and Caucasian Subjects: An Open-Label, Single-Center, Phase 1 Study
    Duanduan Cong
    Jie Song
    Yue Liu
    Yan Tan
    Wei Xue
    Xiaohui Liu
    Wenyuan Qi
    Jun Lu
    Xiaojuan Yuan
    Yongchun Zhou
    Ai-Min Hui
    Kexin Li
    Neurology and Therapy, 2022, 11 : 283 - 301
  • [40] Pharmacokinetics, Pharmacodynamics, and Tolerability of Opicapone in Healthy Chinese and Caucasian Subjects: An Open-Label, Single-Center, Phase 1 Study
    Cong, Duanduan
    Song, Jie
    Liu, Yue
    Tan, Yan
    Xue, Wei
    Liu, Xiaohui
    Qi, Wenyuan
    Lu, Jun
    Yuan, Xiaojuan
    Zhou, Yongchun
    Hui, Ai-Min
    Li, Kexin
    NEUROLOGY AND THERAPY, 2022, 11 (01) : 283 - 301