THE PNPLA3 I148M VARIANT INITIATES METABOLIC REPROGRAMMING IN MACROPHAGES

被引：0
|
作者：
Dixon, Emmanuel [1 ]
Claudel, Thierry [1 ]
Genger, Jakob-Wendelin [1 ]
Zhu, Ci [1 ]
Stadlmayr, Sarah [1 ]
Paolini, Erika [2 ]
Nardo, Alexander [1 ]
Mlitz, Veronika [1 ]
Fuchs, Claudia [1 ]
Bergthaler, Andreas [1 ]
Dongiovanni, Paola [2 ]
Ellmeier, Wilfried [1 ]
Trauner, Michael [1 ]
机构：
[1] Med Univ Vienna, Vienna, Austria
[2] Med Univ Milan, Milan, Italy
来源：
HEPATOLOGY | 2024年 / 80卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
2629
引用
收藏
页码：S1990 / S1991
页数：2
相关论文
共 50 条
  • [41] The Genetic Variant I148M in PNPLA3 Is Associated With Increased Hepatic Retinyl-Palmitate Storage in Humans
    Kovarova, Marketa
    Koenigsrainer, Ingmar
    Koenigsrainer, Alfred
    Machicao, Fausto
    Haering, Hans-Ulrich
    Schleicher, Erwin
    Peter, Andreas
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (12): : E1568 - E1574
  • [42] PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
    Burza, Maria Antonella
    Pirazzi, Carlo
    Maglio, Cristina
    Sjoholm, Kajsa
    Mancina, Rosellina Margherita
    Svensson, Per-Arne
    Jacobson, Peter
    Adiels, Martin
    Baroni, Marco Giorgio
    Boren, Jan
    Corradini, Stefano Ginanni
    Montalcini, Tiziana
    Sjostrom, Lars
    Carlsson, Lena Mariana Susann
    Romeo, Stefano
    DIGESTIVE AND LIVER DISEASE, 2012, 44 (12) : 1037 - 1041
  • [43] Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
    Linden, Daniel
    Ahnmark, Andrea
    Pingitore, Piero
    Ciociola, Ester
    Ahlstedt, Ingela
    Andreasson, Anne-Christine
    Sasidharan, Kavitha
    Madeyski-Bengtson, Katja
    Zurek, Magdalena
    Mancina, Rosellina M.
    Lindblom, Anna
    Bjursell, Mikael
    Bottcher, Gerhard
    Stahlman, Marcus
    Bohlooly-Y, Mohammad
    Haynes, William G.
    Carlsson, Bjorn
    Graham, Mark
    Lee, Richard
    Murray, Sue
    Valenti, Luca
    Bhanot, Sanjay
    Akerblad, Peter
    Romeo, Stefano
    MOLECULAR METABOLISM, 2019, 22 : 49 - 61
  • [44] Pnpla3 Silencing with Antisense Oligonucleotides Ameliorates Nonalcoholic Steatohepatitis and Fibrosis in Pnpla3 I148M Knock-in Mice
    Linden, Daniel
    Ahnmark, Andrea
    Pingitore, Piero
    Ciociola, Ester
    Ahlstedt, Ingela
    Andreasson, Anne-Christine
    Madeyski-Bengtson, Katja
    Zurek, Magdalena
    Mancina, Rosellina M.
    Lindblom, Anna
    Bjurse, Mikael
    Bottcher, Gerhard
    Bohlooly-Y, Mohammad
    Haynes, Wiliam G.
    Carlsson, Bjorm
    Graham, Mark
    Lee, Richard
    Murray, Sue
    Valenti, Luca
    Bhanor, Sanjay
    Akerblad, Peter
    Romeo, Stefano
    HEPATOLOGY, 2018, 68 : 440A - 441A
  • [45] Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals
    Su, Huan
    Haque, Madhuri
    Becker, Svea
    Edlund, Karolina
    Duda, Julia
    Wang, Qingbi
    Reissing, Johanna
    Marschall, Hanns-Ulrich
    Candels, Lena S.
    Mohamed, Mohamed
    Sjoland, Wilhelm
    Liao, Lijun
    Drexler, Stephan A.
    Strowig, Till
    Rahnenfuehrer, Joerg
    Hengstler, Jan G.
    Hatting, Maximilian
    Trautwein, Christian
    LIVER INTERNATIONAL, 2023, 43 (08) : 1699 - 1713
  • [46] PNPLA3 I148M is involved in the variability in anti-NAFLD response to exenatide
    Yunzhi Chen
    Xuemei Yan
    Xiao Xu
    Shuhua Yuan
    Fen Xu
    Hua Liang
    Endocrine, 2020, 70 : 517 - 525
  • [47] PNPLA3 I148M is involved in the variability in anti-NAFLD response to exenatide
    Chen, Yunzhi
    Yan, Xuemei
    Xu, Xiao
    Yuan, Shuhua
    Xu, Fen
    Liang, Hua
    ENDOCRINE, 2020, 70 (03) : 517 - 525
  • [48] The Association Between The PNPLA3 I148M Polymorphism And Nonalcoholic Fatty Liver Disease
    Yuksel, Emine Berrin
    Kilciler, Ayse Guldem
    Koyuncu, Betul
    Balantekin, Cem
    Kutluana, Ufuk
    Erdogan, Beyza Doganay
    GAZI MEDICAL JOURNAL, 2020, 31 (04): : 636 - 639
  • [49] PNPLA3 I148M Polymorphism, Clinical Presentation, and Survival in Patients with Hepatocellular Carcinoma
    Valenti, Luca
    Motta, Benedetta Maria
    Soardo, Giorgio
    Iavarone, Massimo
    Donati, Benedetta
    Sangiovanni, Angelo
    Carnelutti, Alessia
    Dongiovanni, Paola
    Rametta, Raffaela
    Bertelli, Cristina
    Facchetti, Floriana
    Colombo, Massimo
    Fargion, Silvia
    Fracanzani, Anna Ludovica
    PLOS ONE, 2013, 8 (10):
  • [50] Phase 1 Trials of PNPLA3 siRNA in I148M Homozygous Patients with MAFLD
    Fabbrini, Elisa
    Rady, Brian
    Koshkina, Anastasiya
    Jeon, Jae Yoon
    Ayyar, Vivaswath S.
    Gargano, Cynthia
    DiProspero, Nicholas
    Wendel, Susan
    Hegge, Julia
    Hamilton, Holly
    Ding, Zhi-Ming
    Afrazi, Maria
    Nicholas, Anthony
    Pei, Tao
    Nakano, Masayoshi
    Ouchi, Shohei
    Saito, Yuki
    Yamashita, Aimi
    Tamamura, Ryo
    Salazar, Hernan
    Shapiro, Craig
    Yoshihara, Tatsuya
    Yonemura, Takuma
    Inoue, Satoshi
    Matsuoka, Osamu
    Erion, Mark
    Pocai, Alessandro
    Makimura, Hideo
    NEW ENGLAND JOURNAL OF MEDICINE, 2024, 391 (05):
12345