Synthesis and Bio-Evaluation of Quaternized Fused-β-Carbolines as Anti-MRSA Agents

被引：0

作者：

Vutla, Adilakshmi ^{[1
,3
]}

Saxena, Deepanshi ^{[2
]}

Maitra, Rahul ^{[2
]}

Chopra, Sidharth ^{[2
,3
]}

Batra, Sanjay ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10, Lucknow 226031, Uttar Pradesh, India

[2] CSIR Cent Drug Res Inst, Mol Microbiol & Immunol Div, Sect 10, Lucknow 226031, Uttar Pradesh, India

[3] CSIR Human Resource Dev Ctr CSIR HRDC, Acad Sci & Innovat Res, Campus Sect 19, Ghaziabad 201002, Uttar Pradesh, India

来源：

CHEMMEDCHEM | 2025年

关键词：

beta-carboline; Mannich reaction; Antibacterial; Aza-heterocycle; S; aureus; STAPHYLOCOCCUS-AUREUS; DERIVATIVES; PREVALENCE;

D O I：

10.1002/cmdc.202400955

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The drastic increase in the emergence of methicillin and vancomycin resistant S. aureus has resulted in almost negligible treatment options available to tackle these drug-resistant strains and therefore, search for newer antibiotics is essential. In this context, a new series of quaternized fused beta-carbolines was synthesized and evaluated for its anti-bacterial potential. Several compounds from the series displayed potent anti-bacterial activity against Gram-positive bacteria including the drug-resistant strains with minimal cytotoxicity and promising bactericidal action.

引用

页数：9

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