A new diphenyl ether with insecticidal activity from the mangrove endophytic fungus Aspergillus sp. GXNU-DY2-12

被引：0

作者：

Tan, Meijing ^{[1
]}

Ju, Shichao ^{[1
]}

He, Fan ^{[1
]}

Li, Wenjun ^{[1
]}

Wei, Youquan ^{[1
]}

Xu, Weifeng ^{[1
]}

Yang, Ruiyun ^{[1
]}

Huang, Xishan ^{[1
]}

机构：

[1] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Key Lab Chem & Mol Engn Med Resources, Minist Educ China,Collaborat Innovat Ctr Guangxi E, Guilin 541004, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2025年

基金：

中国国家自然科学基金;

关键词：

Diphenyl ether; Aspergillus sp; endophytic fungus; acetylcholinesterase activity; insecticidal activity;

D O I：

10.1080/14786419.2025.2476201

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new diphenyl ether pseudopithoether C (1), and five known compounds (2-6) were purified from secondary metabolites of the Aspergillus sp. GXNU-DY2-12 cultured in the rice medium. The new structure was analysed by NMR, HR-ESI-MS, and X-ray single crystal diffractometer. Compound 1 showed potent acetylcholinesterase (AChE) - inhibiting activity and its IC50 value was 1.02 mu M. Notably, it demonstrated remarkable insecticidal efficacy against Diaphorina citri Kuwayama, achieving a mortality rate of 88% under standardised bioassay conditions.

引用

页数：9

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